Obstructive sleep apnea syndrome (OSAS) is a common disease and an important public health problem. The etiology is poorly understood and quality research is limited. OSAS is associated with an increased incidence of myocardial infarction, cerebrovascular accidents, hypertension, and congestive heart failure. OSAS causes daytime fatigue and poor work performance. For instance, fall-asleep car accidents have become more common than alcohol related accidents. It is estimated that 98% of adults with OSAS lack specific upper airway pathology, such as neoplastic lesions or metabolic enlargement of pharyngeal soft tissue. Thus, the cause of most obstruction is not known. Research evaluation of the upper airway for both pre- and post-operative patients is needed to determine the specific change in airflow and anatomy. Few studies have analyzed the anatomic outcome for OSAS treatment. It is difficult to compare and predict the 3-dimensional anatomy in patients with OSAS. Clinicians assume treatment modalities increase the upper airway but scientific evidence is poor. The computer-aided engineering (CAE) plays an important role in the engineering community for design, analyses, and performance predictions. CAE provides the computational engineers with computing resources that were unimaginable just a decade ago. The Computational Fluid Dynamics (CFD) and associated enabling technology in high-fidelity computational simulations facilitate numerical geometry modeling, numerical mesh generation, flow field simulations, scientific visualization, and high-performance parallel computing. These applications can greatly help medicine to understand the dynamics and behaviors of a human body as well as design of medical treatment. This proposal is to utilize CFD to predict the presence, severity, and outcomes of OSAS by using computed tomographic scans and polysomnography data of adult obstructive sleep apnea patients following maxillomandibular advancement. Our goal is to more accurately identify the anatomical changes in the airway following surgery and improve presurgical prognosis. Project Narrative: Obstructive sleep apnea syndrome (OSAS) is a common disease and an important public health problem. These applications can greatly help medicine to understand the dynamics and behaviors of a human body as well as design of medical treatment.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21DE017613-02
Application #
7666253
Study Section
Special Emphasis Panel (ZDE1-JH (26))
Program Officer
Drummond, James
Project Start
2008-08-01
Project End
2011-07-31
Budget Start
2009-08-01
Budget End
2011-07-31
Support Year
2
Fiscal Year
2009
Total Cost
$217,500
Indirect Cost
Name
University of Alabama Birmingham
Department
Dentistry
Type
Schools of Dentistry
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Cheng, Gary C; Koomullil, Roy P; Ito, Yasushi et al. (2014) Assessment of Surgical Effects on Patients with Obstructive Sleep Apnea Syndrome Using Computational Fluid Dynamics Simulations. Math Comput Simul 106:44-59
Sittitavornwong, Somsak; Waite, Peter D; Shih, Alan M et al. (2013) Computational fluid dynamic analysis of the posterior airway space after maxillomandibular advancement for obstructive sleep apnea syndrome. J Oral Maxillofac Surg 71:1397-405
Ito, Yasushi; Cheng, Gary C; Shih, Alan M et al. (2011) Patient-Specific Geometry Modeling and Mesh Generation for Simulating Obstructive Sleep Apnea Syndrome Cases by Maxillomandibular Advancement. Math Comput Simul 81:1876-1891