New therapeutic approaches in diabetes based on novel glucose sensors and programmable insulin pump are nearing clinical introduction, but there are unknowns about the insulin dynamics and quality of control that may be achievable. The overall objective is to develop a set of instructions or control laws for optimal insulin administration based on frequent or continuous glucose determination, such as that provided by novel glucose sensors being developed by us and others. The project will reply on published human data collected by conventional blood glucose sampling, where available, rather than carrying out new experimental studies. Our present methods for blood glucose prediction based on recent blood glucose values will be extended to greater prediction horizons. Systems identification methodology will be used to establish glucose and insulin dynamic models, which will serve as a basis for development and validation of adaptive controllers for glycemic regulation by sensors and insulin pumps. Means will be developed for comparing the degree of control achievable with methods to control based on Hba1c and frequent fingerstick determinations. Specific human data and collection protocols for later application to individual patients will be identified.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21DK057109-01
Application #
6053431
Study Section
Special Emphasis Panel (ZRG1-END (01))
Program Officer
Harmon, Joan T
Project Start
1999-09-30
Project End
2001-08-31
Budget Start
1999-09-30
Budget End
2000-08-31
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Engineering (All Types)
Type
Schools of Arts and Sciences
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093