? It is proposed to develop a non-invasive thermal system for quantitative measurement of blood perfusion. The main goal is to design and build a clinical device that will be easy to use, automated and accurate for a wide variety of applications. Two different preliminary designs will be developed and tested to demonstrate their different features of operation and safety. Because blood perfusion represents the local, multi-directional blood flow through capillaries and intracellular spaces of living tissue, it is difficult to quantify with absolute values. Consequently, a second goal is to develop a standard in-vitro system for absolute calibration of perfusion measurement systems. Two different proposed thermal systems will be compared along with a laser Doppler system in this calibration device to determine performance against an absolute standard. The measurement systems will also be compared by testing in vivo in rats. At the end of this two year project a calibration system and two measurement systems will have been designed, built, and tested. Based on their assessed performance the appropriate applications will be pursued in future studies using the resources of the Veterinary School, the Wake Forest Medical School and the Carilion Biomedical Institute affiliated with Virginia Tech. ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21EB003943-02
Application #
6921969
Study Section
Special Emphasis Panel (ZRR1-BT-5 (01))
Program Officer
Korte, Brenda
Project Start
2004-07-15
Project End
2007-06-30
Budget Start
2005-07-01
Budget End
2007-06-30
Support Year
2
Fiscal Year
2005
Total Cost
$181,432
Indirect Cost
Name
Virginia Polytechnic Institute and State University
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
003137015
City
Blacksburg
State
VA
Country
United States
Zip Code
24061
Mudaliar, Ashvinikumar V; Ellis, Brent E; Ricketts, Patricia L et al. (2008) Noninvasive blood perfusion measurements of an isolated rat liver and an anesthetized rat kidney. J Biomech Eng 130:061013
Mudaliar, Ashvinikumar V; Ellis, Brent E; Ricketts, Patricia L et al. (2008) A phantom tissue system for the calibration of perfusion measurements. J Biomech Eng 130:051002
Ricketts, Patricia L; Mudaliar, Ashvinikumar V; Ellis, Brent E et al. (2008) Non-Invasive Blood Perfusion Measurements Using a Combined Temperature and Heat Flux Surface Probe. Int J Heat Mass Transf 51:5740-5748