This R21 Clinical Vision Research Development Award is designed to enhance the clinical research activities and capabilities of investigators in the Visual Sciences Research Center (VSRC) at Case Western Reserve University (CWRU). The CWRU VSRC, based in the Department of Ophthalmology, encompasses over 30 vision science researchers, 12 basic and clinical departments at CWRU, and 3 affiliated hospitals. The VSRC has an already established and excellent basic science research program as evidenced by 17 current R01 and R03 awards, a P30 Core Grant and T32 Training Grant. The next goal of the VSRC is to expand and strengthen resources to establish a strong clinical vision research program. This R21 award will allow for the expansion of the VSRC Clinical Research Unit and the creation of a VSRC Biostatistics Unit, two resources critical to the continued development of clinical vision research at CWRU. Under the direction of Jonathan Lass, M.D., PI of this proposed project and the current P30 Core Grant, Director of the VSRC, and Chairman of the CWRU Department of Ophthalmology, our specific aims are as follows: 1) expand the resources, knowledge, and staff of our existing Clinical Research Unit, 2) establish a Biostatistics Unit which will be self sufficient in serving all the study design, data analysis, and data reporting needs of our clinical investigators, and 3) ultimately establish data coordinating center capabilities and activities. Together with a strong basic science program and an expanding clinical science program made possible through this R21 award, we seek to place the CWRU VSRC as one of the leading visual sciences research centers in this country. ? ?

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21EY015145-05
Application #
7386570
Study Section
Special Emphasis Panel (ZEY1-VSN (03))
Program Officer
Redford, Maryann
Project Start
2004-04-01
Project End
2010-03-31
Budget Start
2008-04-01
Budget End
2010-03-31
Support Year
5
Fiscal Year
2008
Total Cost
$145,596
Indirect Cost
Name
Case Western Reserve University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Afshari, Natalie A; Igo Jr, Robert P; Morris, Nathan J et al. (2017) Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy. Nat Commun 8:14898
Verhoeven, Virginie J M; Hysi, Pirro G; Wojciechowski, Robert et al. (2013) Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia. Nat Genet 45:314-8
Price, Marianne O; Gorovoy, Mark; Price Jr, Francis W et al. (2013) Descemet's stripping automated endothelial keratoplasty: three-year graft and endothelial cell survival compared with penetrating keratoplasty. Ophthalmology 120:246-51
Zhang, Xiaolin; Igo Jr, Robert P; Fondran, Jeremy et al. (2013) Association of smoking and other risk factors with Fuchs' endothelial corneal dystrophy severity and corneal thickness. Invest Ophthalmol Vis Sci 54:5829-35
Igo Jr, Robert P; Kopplin, Laura J; Joseph, Peronne et al. (2012) Differing roles for TCF4 and COL8A2 in central corneal thickness and fuchs endothelial corneal dystrophy. PLoS One 7:e46742
Louttit, Megan D; Kopplin, Laura J; Igo Jr, Robert P et al. (2012) A multicenter study to map genes for Fuchs endothelial corneal dystrophy: baseline characteristics and heritability. Cornea 31:26-35
Kopplin, Laura J; Przepyszny, Katie; Schmotzer, Brian et al. (2012) Relationship of Fuchs endothelial corneal dystrophy severity to central corneal thickness. Arch Ophthalmol 130:433-9
Nagarsheth, Mehul; Singh, Annapurna; Schmotzer, Brian et al. (2012) Relationship Between Fuchs Endothelial Corneal Dystrophy Severity and Glaucoma and/or Ocular Hypertension. Arch Ophthalmol 130:1384-8
Diaz, Mireya; Norell, Marie; Belkin, Julie et al. (2011) Cognitive profile of elders in an ophthalmic ambulatory setting. Br J Ophthalmol 95:24-7
Price, Marianne O; Gorovoy, Mark; Benetz, Beth A et al. (2010) Descemet's stripping automated endothelial keratoplasty outcomes compared with penetrating keratoplasty from the Cornea Donor Study. Ophthalmology 117:438-44

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