One of affective neuroscience is the of detailed animal models for fear learning that have been confirmed and extended in investigations with humans. The neural systems identified in these animal models, which have relied on fear conditioning as a basic paradigm, have been implicated in the development of psychological disorders, such as anxiety disorders and drug addiction. Understanding the neural circuits important for the development of these disorders is a first step in linking basic science to their treatment. The next step is to understand how these learned emotional responses can be extinguished or altered by action. The goal of the proposed research is to explore the neural mechanisms underlying the extinction and active coping of conditioned fear across human and non-human species and as they are altered with anxiety disorders. ? ? There are three specific aims: ? Aim 1: To develop paradigms of extinction and fear coping that are similar across species allowing for the exploration of specific neural mechanisms in rodents that can be assessed using less invasive techniques in humans. ? Aim 2: To determine the link between the neural mechanisms of fear inhibition through extinction with the mechanisms underlying active coping/emotion regulation strategies. ? Aim 3: To assess how the behavioral expression and neural mechanisms underlying fear extinction and active coping differs between normal subjects and patients suffering from anxiety disorders. ? ? ?
| Schiller, Daniela; Raio, Candace M; Phelps, Elizabeth A (2012) Extinction training during the reconsolidation window prevents recovery of fear. J Vis Exp :e3893 |
| Hartley, Catherine A; McKenna, Morgan C; Salman, Rabia et al. (2012) Serotonin transporter polyadenylation polymorphism modulates the retention of fear extinction memory. Proc Natl Acad Sci U S A 109:5493-8 |
| Hartley, Catherine A; Fischl, Bruce; Phelps, Elizabeth A (2011) Brain structure correlates of individual differences in the acquisition and inhibition of conditioned fear. Cereb Cortex 21:1954-62 |
| Schiller, Daniela; Phelps, Elizabeth A (2011) Does reconsolidation occur in humans? Front Behav Neurosci 5:24 |
| Schiller, Daniela; Monfils, Marie-H; Raio, Candace M et al. (2010) Preventing the return of fear in humans using reconsolidation update mechanisms. Nature 463:49-53 |
| Schiller, Daniela; Delgado, Mauricio R (2010) Overlapping neural systems mediating extinction, reversal and regulation of fear. Trends Cogn Sci 14:268-76 |
| Sotres-Bayon, Francisco; Diaz-Mataix, Llorenç; Bush, David E A et al. (2009) Dissociable roles for the ventromedial prefrontal cortex and amygdala in fear extinction: NR2B contribution. Cereb Cortex 19:474-82 |
| Schiller, Daniela; Levy, Ifat; Niv, Yael et al. (2008) From fear to safety and back: reversal of fear in the human brain. J Neurosci 28:11517-25 |
| Delgado, Mauricio R; Nearing, Katherine I; Ledoux, Joseph E et al. (2008) Neural circuitry underlying the regulation of conditioned fear and its relation to extinction. Neuron 59:829-38 |
| Schiller, Daniela; Cain, Christopher K; Curley, Nina G et al. (2008) Evidence for recovery of fear following immediate extinction in rats and humans. Learn Mem 15:394-402 |
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