Bipolar disorder is a chronic mental illness affecting up to 3% of the population. It is one of the top ten causes of disability worldwide, yet the neurophysiologic basis of the disorder remains unknown. The use of functional neuroimaging techniques (e.g. fMRI, PET) in combination with neuropsychological (activation) paradigms has served to deepen our understanding of regional brain dysfunction in psychiatric disorders, but the application of such types of functional studies to patients with bipolar disorder has been minimal. This application proposes to combine a neuropsychological paradigm with fMRI data to map functional data to structural MRI data. This has not, to our knowledge, been attempted in the bipolar population. We will use novel computational anatomy techniques to develop average anatomic representations for coregistration with fMRI images in bipolar subjects and compare this to normal controls. This approach will be used to assess the relationship between brain functional deficits seen on fMRI in patients with bipolar disorder and the structural integrity/volume of brain gray and white matter. Using such methods, we hope to clarify whether gray and/or white matter structural deficits are associated with the reduction in neural activity seen in fMRI. This exploration may clarify the neural/biologic underpinnings of bipolar disorder. The discovery of specific anatomic abnormalities that are associated with clear functional consequences may direct the pursuit of targeted neuropharmacologic development and lead to better treatments for bipolar patients. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21MH075944-01A1
Application #
7141850
Study Section
Neural Basis of Psychopathology, Addictions and Sleep Disorders Study Section (NPAS)
Program Officer
Meinecke, Douglas L
Project Start
2006-07-01
Project End
2008-06-30
Budget Start
2006-07-01
Budget End
2007-06-30
Support Year
1
Fiscal Year
2006
Total Cost
$208,575
Indirect Cost
Name
University of California Los Angeles
Department
Psychiatry
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
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Brooks 3rd, J O; Vizueta, N; Penfold, C et al. (2015) Prefrontal hypoactivation during working memory in bipolar II depression. Psychol Med 45:1731-40
Ajilore, Olusola; Vizueta, Nathalie; Walshaw, Patricia et al. (2015) Connectome signatures of neurocognitive abnormalities in euthymic bipolar I disorder. J Psychiatr Res 68:37-44
Townsend, Jennifer D; Sugar, Catherine A; Walshaw, Patricia D et al. (2013) Frontostriatal neuroimaging findings differ in patients with bipolar disorder who have or do not have ADHD comorbidity. J Affect Disord 147:389-96
Foland-Ross, Lara C; Thompson, Paul M; Sugar, Catherine A et al. (2013) Three-dimensional mapping of hippocampal and amygdalar structure in euthymic adults with bipolar disorder not treated with lithium. Psychiatry Res 211:195-201
Townsend, Jennifer D; Torrisi, Salvatore J; Lieberman, Matthew D et al. (2013) Frontal-amygdala connectivity alterations during emotion downregulation in bipolar I disorder. Biol Psychiatry 73:127-35
Barysheva, Marina; Jahanshad, Neda; Foland-Ross, Lara et al. (2013) White matter microstructural abnormalities in bipolar disorder: A whole brain diffusion tensor imaging study. Neuroimage Clin 2:558-68
Torrisi, Salvatore; Moody, Teena D; Vizueta, Nathalie et al. (2013) Differences in resting corticolimbic functional connectivity in bipolar I euthymia. Bipolar Disord 15:156-66
Torgerson, Carinna M; Irimia, Andrei; Leow, Alex D et al. (2013) DTI tractography and white matter fiber tract characteristics in euthymic bipolar I patients and healthy control subjects. Brain Imaging Behav 7:129-39
Townsend, Jennifer D; Bookheimer, Susan Y; Foland-Ross, Lara C et al. (2012) Deficits in inferior frontal cortex activation in euthymic bipolar disorder patients during a response inhibition task. Bipolar Disord 14:442-50

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