Cardiovascular disease (CVD) is the leading cause of death and disability in the United States (US). National data show that African Americans carry an undue burden of this chronic disease, indicating the presence of significant health disparities. Surveillance data also show extensive geographical disparities, wherein Southern states, where a majority of African Americans reside, have the highest age-adjusted rates of morbidity and mortality from heart disease. CVD, like most non-communicable diseases, is multifactorial in nature- determined by biologic, behavioral and environmental factors. While much recent research has focused on the influences of neighborhood characteristics on health and health-related behaviors, few studies have examined their role in predominantly high-risk minority populations like African Americans. And those that have show a lack of clarity and consistency on the role of neighborhood characteristics in health and health-related behaviors. Diet is a significant predictor of CVD and coronary heart disease (CHD) risk and recently, the study of dietary patterns has emerged as a promising area in nutrition research. Dietary interventions have also emphasized the role of dietary patterns in reducing the risk of CVD. However, for nutritional interventions to be effective, they must consider existing dietary patterns followed by their target population. Dietary intake patterns of Africans Americans are significantly different from the general US population. No studies that we are aware have examined the relationship between neighborhood characteristics and dietary patterns and CVD risk in large southern African American populations. In this study, we propose to address this significant gap, by conducting a study to: a) determine the associations between neighborhood characteristics and individual dietary patterns. Neighborhood characteristics examined include neighborhood socio-economic status, availability of and proximity to fast food restaurants, food stores, and parks and recreational facilities, while individual-level dietary patterns include a priori (2005-Healthy Eating Index) and a posteriori (factor analysis derived) dietary patterns;b) determine whether neighborhood characteristics and individual dietary patterns are associated with sub-clinical atherosclerosis;c) describe the relationships between neighborhood characteristics and individual dietary patterns, with: i) incident CHD, ii) hypertension, iii) dyslipidemia, and iv) abdominal subcutaneous and visceral adipose tissue in an NIH-supported, largest single-site, population- based, prospective, observational, all African American cohort, located in Jackson, Mississippi, the Jackson Heart Study. We plan to examine these relationships using neighborhood and dietary data that have been collected at baseline, and outcomes assessed at baseline, 4- and 5- y follow-up of the Jackson Heart Study. We believe that the results of the proposed study will fill a critical gap in knowledge and will help clinicians and policymakers design effective and targeted intervention programs and policy recommendations to prevent the onset and delay the progression of CVD in an under-studied, high-risk minority population.

Public Health Relevance

Cardiovascular disease is the leading cause of morbidity and mortality in United States and affects African Americans disproportionately. It is therefore critical that we have a better understanding of the factors influencing cardiovascular disease risk in African Americans. Neighborhood characteristics and diet are examples of such potentially modifiable factors, and the study of these relationships is likely to guide the development of improved interventions and policy recommendations to ameliorate these health disparities.

Agency
National Institute of Health (NIH)
Institute
National Institute of Nursing Research (NINR)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21NR013231-01
Application #
8229047
Study Section
Cardiovascular and Sleep Epidemiology (CASE)
Program Officer
Huss, Karen
Project Start
2012-03-06
Project End
2014-02-28
Budget Start
2012-03-06
Budget End
2013-02-28
Support Year
1
Fiscal Year
2012
Total Cost
$220,020
Indirect Cost
$47,648
Name
Northeastern University
Department
Other Health Professions
Type
Schools of Allied Health Profes
DUNS #
001423631
City
Boston
State
MA
Country
United States
Zip Code
02115
Auerbach, Brandon J; Katz, Ronit; Tucker, Katherine et al. (2017) Factors associated with maintenance of body mass index in the Jackson Heart Study: A prospective cohort study secondary analysis. Prev Med 100:95-100
Weaver, Anne M; Wellenius, Gregory A; Wu, Wen-Chih et al. (2017) Residential distance to major roadways and cardiac structure in African Americans: cross-sectional results from the Jackson Heart Study. Environ Health 16:21
Muntner, Paul; Abdalla, Marwah; Correa, Adolfo et al. (2017) Hypertension in Blacks: Unanswered Questions and Future Directions for the JHS (Jackson Heart Study). Hypertension 69:761-769
Weaver, Anne M; Wellenius, Gregory A; Wu, Wen-Chih et al. (2016) Residential Proximity to Major Roadways Is Not Associated with Cardiac Function in African Americans: Results from the Jackson Heart Study. Int J Environ Res Public Health 13:
Djoussé, Luc; Petrone, Andrew B; Hickson, DeMarc A et al. (2016) Egg consumption and risk of type 2 diabetes among African Americans: The Jackson Heart Study. Clin Nutr 35:679-84
Wang, Yi; Wellenius, Gregory A; Hickson, DeMarc A et al. (2016) Residential Proximity to Traffic-Related Pollution and Atherosclerosis in 4 Vascular Beds Among African-American Adults: Results From the Jackson Heart Study. Am J Epidemiol 184:732-743
Djoussé, Luc; Petrone, Andrew B; Blackshear, Chad et al. (2015) Prevalence and changes over time of ideal cardiovascular health metrics among African-Americans: the Jackson Heart Study. Prev Med 74:111-6
Liu, Jiankang; Hickson, Demarc A; Musani, Solomon K et al. (2012) Dietary Patterns, Abdominal Visceral Adipose Tissue and Cardiometabolic Risk Factors in African Americans: the Jackson Heart Study. Obesity (Silver Spring) :