The skin is densely innervated with sensory neuronal fibers that synthesize several neuropeptides, including the eleven residue tachykinin, substance P (SP). Among SP effects are inflammation mediation and subsequent wound healing. Major objectives of this study are to: (1) determine the optimum time and dose of streptozotocin for the development of a diabetic rat model by measurement of SP content and SP containing nerve density; (2) to evaluate SP depletion in cutaneous nerves in the streptozotocin diabetic rat model of type I diabetes, using immunohistochemical analysis; (3) to determine the stability of formulations of SP and SP analogs under different time and temperature conditions; and (4) to develop SP and SP analog treatments for wound healing in the streptozotocin rat model of type I diabetes. The long- term goal is ultimately to develop effective SP therapies for use in promoting wound healing in diabetic patients.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Exploratory/Developmental Grants (R21)
Project #
1R21NS038847-01
Application #
2759049
Study Section
Special Emphasis Panel (ZRG2-NMS (01))
Program Officer
Nichols, Paul L
Project Start
1998-09-30
Project End
2000-08-31
Budget Start
1998-09-30
Budget End
1999-08-31
Support Year
1
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Texas Tech University
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
609980727
City
Lubbock
State
TX
Country
United States
Zip Code
79430