Given our long-term goal to discover new therapeutic approaches that can improve patient outcomes, we will investigate a novel therapeutic strategy, intranasal drug delivery, aiming to inhibit the invasion of glioma cells. The proposed studies are the first, to our knowledge, to simultaneously target two clinically relevant hallmarks associated with malignant glioma: angiogenesis and invasion. These data should provide exploratory information leading towards the development of novel therapies for glioma patients.
Esencay, Mine; Sarfraz, Yasmeen; Zagzag, David (2013) CXCR7 is induced by hypoxia and mediates glioma cell migration towards SDF-1?. BMC Cancer 13:347 |
Williams, Susan C; Karajannis, Matthias A; Chiriboga, Luis et al. (2011) R132H-mutation of isocitrate dehydrogenase-1 is not sufficient for HIF-1? upregulation in adult glioma. Acta Neuropathol 121:279-81 |