The objectives of this proposal are: [1] to develop the necessary resources, including human resources at or/and associated with Debub University, Southern Ethiopia, supported by collaborations with and between the University of Colorado Health Sciences Center and Oklahoma State University, to initiate and sustain a durable research program linking nutrition [micronutrients] and maternal-child brain development and function; [2] to complete pilot studies that will provide an essential cornerstone for the development of a major R01 grant proposal that will be designed to test the following hypotheses: Provision of an optimal quantity of bioavailable zinc during the second and third trimesters of pregnancy and to offspring through the first 2 years will be associated with improved maternal cognitive and behavioral; greater head circumference of neonate [adjusted for gestational age] and improved attention/habituation/intellectual and motor development throughout the first 2 years of life and beyond. These objectives will be achieved by: fully developing a research team in Awassa and associated institutions; an initial planning, consortium-building, needs assessment meeting in Awassa; supporting the development of an IRB with FWA at Debub University; training and cross-training [nutrition and brain function research] in Awassa, Colorado and Oklahoma; pilot testing of tools for studies of brain function in Awassa; pilot nutrition studies including: dietary, biomarker and anthropometrics assessment; assessment of zinc nutritional status, zinc absorption and zinc requirements for this particular population; a second planning meeting to review progress and plan details of R01 proposal; and, finally, the development of the R01 proposal based on the experience and knowledge acquired with this preparatory/pilot R21-supported research.

Agency
National Institute of Health (NIH)
Institute
Fogarty International Center (FIC)
Type
Exploratory/Developmental Grants (R21)
Project #
5R21TW006729-02
Application #
6804085
Study Section
Special Emphasis Panel (ZNS1-SRB-H (01))
Program Officer
Michels, Kathleen M
Project Start
2003-09-28
Project End
2007-02-28
Budget Start
2004-02-29
Budget End
2007-02-28
Support Year
2
Fiscal Year
2004
Total Cost
$139,750
Indirect Cost
Name
University of Colorado Denver
Department
Pediatrics
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
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