This research is aimed at providing an understanding of the mechanisms used by Schistosoma mansoni to survive and multiply in its intermediate host snail Biomphalaria glabrata. S. mansioni is a causative agent of human schistosomiasis, a serious debilitating disease in human populations in many areas of the tropics. On the premise that the compatibility of S. mansoni with B. glabrata is a highly specific phenomenon, and that the specificity is manifested as a result of events occurring at the interface of the sporocyst with host-snail hemocyte plasma membranes, we aim to provide information on the cellular-chemical basis of specificity. Experiments will be designed to yield information which will support or refute various hypotheses that bear directly on the following issues (a) The mechanisms by which snail hemocytes recognize trematode sporocysts (b) The mechanisms by which snails acquire enhanced resistance, of a more or less specific nature, to trematode sporocysts. (c) The mechanisms by which trematode sporocysts avoid destruction by hemocytes of certain snail strains (d) The mechanisms by which trematode sporocysts interfere with innate resistance of snails Methodologies will involve in vitro culture of schistosome sporocysts larvae together with immunocompetent leukocytes (hemocytes) of host sanils. Both susceptible and resistaint strains of snail will be used as sources of hemocytes. Sensitive labelling of potentially important molecules of host and parasite origin will permit us to evaluate their roles in mediation of compatibility.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Unknown (R22)
Project #
2R22AI016137-05
Application #
3444512
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Project Start
1981-09-30
Project End
1988-11-30
Budget Start
1986-12-01
Budget End
1987-11-30
Support Year
5
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Oregon State University
Department
Type
Schools of Arts and Sciences
DUNS #
053599908
City
Corvallis
State
OR
Country
United States
Zip Code
97339
Tavalire, Hannah F; Blouin, Michael S; Steinauer, Michelle L (2016) Genotypic variation in host response to infection affects parasite reproductive rate. Int J Parasitol 46:123-31
Tennessen, Jacob A; Bonner, Kaitlin M; Bollmann, Stephanie R et al. (2015) Genome-Wide Scan and Test of Candidate Genes in the Snail Biomphalaria glabrata Reveal New Locus Influencing Resistance to Schistosoma mansoni. PLoS Negl Trop Dis 9:e0004077
Tennessen, Jacob A; Théron, André; Marine, Melanie et al. (2015) Hyperdiverse gene cluster in snail host conveys resistance to human schistosome parasites. PLoS Genet 11:e1005067
Larson, Maureen K; Bender, Randal C; Bayne, Christopher J (2014) Resistance of Biomphalaria glabrata 13-16-R1 snails to Schistosoma mansoni PR1 is a function of haemocyte abundance and constitutive levels of specific transcripts in haemocytes. Int J Parasitol 44:343-53
Hoffmann, Christopher J; Ledwaba, Johanna; Li, Jin-Fen et al. (2013) Resistance to tenofovir-based regimens during treatment failure of subtype C HIV-1 in South Africa. Antivir Ther 18:915-20
Duwell, Monique M; Knowlton, Amy R; Nachega, Jean B et al. (2013) Patient-nominated, community-based HIV treatment supporters: patient perspectives, feasibility, challenges, and factors for success in HIV-infected South African adults. AIDS Patient Care STDS 27:96-102
Svensson, Elin; van der Walt, Jan-Stefan; Barnes, Karen I et al. (2012) Integration of data from multiple sources for simultaneous modelling analysis: experience from nevirapine population pharmacokinetics. Br J Clin Pharmacol 74:465-76
Bonner, Kaitlin M; Bayne, Christopher J; Larson, Maureen K et al. (2012) Effects of Cu/Zn superoxide dismutase (sod1) genotype and genetic background on growth, reproduction and defense in Biomphalaria glabrata. PLoS Negl Trop Dis 6:e1701
Steinauer, Michelle L; Bonner, Kaitlin M (2012) Host susceptibility is altered by light intensity after exposure to parasites. J Parasitol 98:1052-4
Hoffmann, Christopher J; Fielding, Katherine L; Johnston, Victoria et al. (2011) Changing predictors of mortality over time from cART start: implications for care. J Acquir Immune Defic Syndr 58:269-76

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