Injections of IgD-containing ascites or purified IgD into BALB/c mice cause enhancement of antibody production to trinitrophenylated (TNP) conjugates. Splenic T cells from IgD pretreated mice transfer this enhanced ability to produce antibody to normal recipients. Experiments are proposed to characterize the cells response for this effect and to analyze the regulatory events involved in this phenomenon at the molecular level. The suggested approach is based on the working hypothesis that T cells with Fc receptors for IgD down-regulate IgD transcription and simultaneously stimulate IgM secretion and/or secretion of other Ig isotypes.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Unknown (R23)
Project #
5R23AI022645-02
Application #
3562510
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1985-09-01
Project End
1988-08-31
Budget Start
1986-09-01
Budget End
1987-08-31
Support Year
2
Fiscal Year
1986
Total Cost
Indirect Cost
Name
New York University
Department
Type
DUNS #
004514360
City
New York
State
NY
Country
United States
Zip Code
10012