The primary goals of this project are to study the development of two forms of visual position sensitivity, or hyperacuity, in normal and strabismic infant monkeys. The two forms of hyperacuity to be studied are vernier acuity and stereoacuity. Normal developmental time courses for these visual functions will be compared with that already described for grating acuity. In addition, they will be compared with the time courses found for infant monkeys with experimentally induced strabismus. The proposed experiments are important for several reasons. First, very little is known about the development of spatial position sensitivity yet it is one of the primate visual system's finest known capabilities. Second, strabismic human adults show deficits in visual hyperacuity that are more profound than deficits in resolution acuity, e.g., grating or Snellen acuity. Third, it is thought that the physiological mechanisms underlying hyperacuity and resolution acuity are different. Knowledge of the relative developmental time courses and their relative disruption in strabismus will lend valuable information to the understanding of the underlying processes. An animal model, in this case the monkey, is needed for this work so that the underlying physiological and anatomical processes can be studied in the same species. The monkey was chosen as a model so that the information gained can be extrapolated to the human with relative confidence.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Unknown (R23)
Project #
1R23EY005864-01
Application #
3447791
Study Section
Visual Sciences B Study Section (VISB)
Project Start
1985-09-30
Project End
1988-09-29
Budget Start
1985-09-30
Budget End
1986-09-29
Support Year
1
Fiscal Year
1985
Total Cost
Indirect Cost
Name
New York University
Department
Type
Schools of Arts and Sciences
DUNS #
004514360
City
New York
State
NY
Country
United States
Zip Code
10012
Shooner, Christopher; Hallum, Luke E; Kumbhani, Romesh D et al. (2015) Population representation of visual information in areas V1 and V2 of amblyopic macaques. Vision Res 114:56-67
Kiorpes, Lynne; Mangal, Paul (2015) ""Global"" visual training and extent of transfer in amblyopic macaque monkeys. J Vis 15:14
Li, Da-Peng; Hagan, Maureen A; Kiorpes, Lynne (2013) Linking structure and function: development of lateral spatial interactions in macaque monkeys. Vis Neurosci 30:263-70
Kiorpes, Lynne; Price, Tracy; Hall-Haro, Cynthia et al. (2012) Development of sensitivity to global form and motion in macaque monkeys (Macaca nemestrina). Vision Res 63:34-42
Feltner, Kimberly A; Kiorpes, Lynne (2010) Global visual processing in macaques studied using Kanizsa illusory shapes. Vis Neurosci 27:131-8
Rislove, Elizabeth M; Hall, Elaine C; Stavros, Kara A et al. (2010) Scale-dependent loss of global form perception in strabismic amblyopia. J Vis 10:25
El-Shamayleh, Yasmine; Movshon, J Anthony; Kiorpes, Lynne (2010) Development of sensitivity to visual texture modulation in macaque monkeys. J Vis 10:11