This study aims to examine the epidemiology of the several specific components of late fetal death and neonatal mortality in a very large data set: all births in New York City (NYC) from 1957-1983. One series of analyses will identify the specific components of the declining time trends in perinatal mortality in NYC between the late 1950's and the early 1980's and explore the reasons for it. Within narrow birthweight categories, mortality trends will be examined to see whether they can be explained by changes in the distributions of maternal age, parity, or socioeconomic status of the birth population. Birthweight-specific analyses will be carried out separately for antepartum, intrapartum, and neonatal mortality trends. A specific objective will be to understand the relationship between obstetric intervention in labor and delivery and secular trends in perinatal mortality, especially fetal death during labor. Correlations between mortality and rates of cesarean section, induction of labor, and mid-and high-forceps delivery will be examined in time series regression analyses. Other analyses will examine maternal age and parity in relation to each component of mortality. Over a fourteen year period (1970-1983), fetal deaths during labor will be analyzed with age and parity as continuous variables. Prior fetal loss and socioeconomic indicators will be closely controlled. The role of birthweight, gestational age, and pregnancy complications (e.g. preeclampsia, abnormal uterine bleeding, diabetes) as intervening variables will be explored with path analytic techniques. Special attention will be paid to the risk among women in their thirties having their first birth, and the effect of cesarean section on risk. Birth cohort analyses will be carried out to test the possibility that a woman's birth cohort, rather than her age at delivery, determines mortality risk in her offspring.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Unknown (R23)
Project #
5R23HD020050-03
Application #
3448154
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1985-04-01
Project End
1988-03-31
Budget Start
1987-04-01
Budget End
1988-03-31
Support Year
3
Fiscal Year
1987
Total Cost
Indirect Cost
Name
New York State Psychiatric Institute
Department
Type
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Kiely, J L (1991) Time trends in neonatal mortality among twins and singletons in New York City, 1968-1986. Acta Genet Med Gemellol (Roma) 40:303-9
Kiely, J L (1991) Mode of delivery and neonatal death in 17,587 infants presenting by the breech. Br J Obstet Gynaecol 98:898-904
Kiely, J L (1991) Some conceptual problems in multivariable analyses of perinatal mortality. Paediatr Perinat Epidemiol 5:243-57
Kiely, J L (1990) The epidemiology of perinatal mortality in multiple births. Bull N Y Acad Med 66:618-37
MacLeod, S; Kiely, J L (1988) The effects of maternal age and parity on birthweight: a population-based study in New York City. Int J Gynaecol Obstet 26:11-9