The University of California San Diego Digestive Disease Research Development Center (UCSD DDRDC) goal is to provide the framework to facilitate research productivity, foster new research directions, and encourage collaborations to form among participating members. The Center's theme focuses on the continuum of pathophysiological processes that progress from inflammation to repair to transformation, as highlighted in the disease progression within digestive organs such as the liver and intestine. The Center supports 21 established investigators and 8 junior investigators from 6 departments within the UCSD School of Medicine who share in the understanding and discovery of regulatory mechanisms that drive the inflammation to repair to transformation continuum in digestive organs, and will provide insights that may translate into therapies to control or prevent progression towards transformation. The UCSD DDRDC supports three highly inter-related, service-oriented biomedical Cores that will increase members research potential and productivity. An Animal Model Core provides assistance in the conduct and analysis of animal studies (including models of intestinal inflammation, infection, and xenotransplantation), breeding colony support (including acquisition, establishment, and intial breeding of genetically-engineered mice), and advice and training in animal research. The Imaging Core provides assistance in the approach and design, image data acquisition, and analysis of images obtained utilizing sophisticated microscopy. The Imaging Core also provides assistance, acquisition, and analysis of intracellular ion imaging and concentration determination that can be markedly altered in inflammatory states. The Molecular Pathobiology Core provides assistance in the acquisition and analysis of cells via laser capture microscopy, and provides assistance in the conduct and analysis utilizing fluorescent-based gene expression systems as well as utilizing high-density microarrays. The three cores of the UCSD DDRDC will provide high quality and state of the art experiments for members, increase collaborative activity among the members, and accelerate growth in research development of junior investigators. The UCSD DDRDC synergizes the strong research base of digestive organ investigators at UCSD, and provides a resource-rich and intellectual environment to embolden novel research ideas and interactions that address the inflammation to repair to transformation continuum.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Resource-Related Research Projects (R24)
Project #
5R24DK080506-03
Application #
7789482
Study Section
Special Emphasis Panel (ZDK1-GRB-G (O1))
Program Officer
Podskalny, Judith M,
Project Start
2008-04-10
Project End
2013-02-28
Budget Start
2010-03-01
Budget End
2011-02-28
Support Year
3
Fiscal Year
2010
Total Cost
$540,750
Indirect Cost
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Zarrinpar, Amir; Chaix, Amandine; Xu, Zhenjiang Z et al. (2018) Antibiotic-induced microbiome depletion alters metabolic homeostasis by affecting gut signaling and colonic metabolism. Nat Commun 9:2872
Garcia-Carbonell, Ricard; Wong, Jerry; Kim, Ju Youn et al. (2018) Elevated A20 promotes TNF-induced and RIPK1-dependent intestinal epithelial cell death. Proc Natl Acad Sci U S A 115:E9192-E9200
Marin-Valencia, Isaac; Novarino, Gaia; Johansen, Anide et al. (2018) A homozygous founder mutation in TRAPPC6B associates with a neurodevelopmental disorder characterised by microcephaly, epilepsy and autistic features. J Med Genet 55:48-54
Widjaja, Christella E; Olvera, Jocelyn G; Metz, Patrick J et al. (2017) Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification. J Clin Invest 127:3609-3623
Metz, Patrick J; Lopez, Justine; Kim, Stephanie H et al. (2016) Regulation of Asymmetric Division by Atypical Protein Kinase C Influences Early Specification of CD8(+) T Lymphocyte Fates. Sci Rep 6:19182
den Hartog, Gerco; Chattopadhyay, Ranajoy; Ablack, Amber et al. (2016) Regulation of Rac1 and Reactive Oxygen Species Production in Response to Infection of Gastrointestinal Epithelia. PLoS Pathog 12:e1005382
Banno, Asoka; Garcia, Daniel A; van Baarsel, Eric D et al. (2016) Downregulation of 26S proteasome catalytic activity promotes epithelial-mesenchymal transition. Oncotarget 7:21527-41
Ngoi, Soo M; Lopez, Justine M; Chang, John T (2016) The Microtubule-Associated Protein Lis1 Regulates T Lymphocyte Homeostasis and Differentiation. J Immunol 196:4237-45
Boland, Brigid S; Boyle, David L; Sandborn, William J et al. (2015) Validation of gene expression biomarker analysis for biopsy-based clinical trials in Crohn's disease. Inflamm Bowel Dis 21:323-30
Frankwich, Karen A; Egnatios, Jeremy; Kenyon, Mandy L et al. (2015) Differences in Weight Loss Between Persons on Standard Balanced vs Nutrigenetic Diets in a Randomized Controlled Trial. Clin Gastroenterol Hepatol 13:1625-1632.e1

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