The goal of this infrastructure development request is to enhance the research environment and accelerate the research objectives of NEI-funded vision scientists at the Medical University of South Carolina (MUSC), facilitate growth, and increase multi-disciplinary collaborative research in the visual system. This request will improve vision research at MUSC by supporting key elements of vision research infrastructure, and by providing new access for vision researchers to cutting edge technology that is not normally supported through the R01 funding mechanism. To accomplish this, two modules are proposed: a Tissue and Organ Culture module, and a Proteomics module. The two modules will be used by at least eight NEI-funded investigators from the Departments of Ophthalmology and Pharmacology who comprise highly interactive and collegial vision research group at MUSC. The infrastructure development grant will be directed by an established vision researcher in the Department of Ophthalmology. Projects benefiting from this infrastructure activity include research on retinoid photochemistry, biology of phototransduction, retinal degeneration, glaucoma, retinal neovascularization, structure-function studies of the retina and retinal pigment epithelium proteins, genetics of photoreceptor development, membrane receptors, lens protein structure in aging and cataractogenesis, and corneal transplantation.

Agency
National Institute of Health (NIH)
Institute
National Eye Institute (NEI)
Type
Resource-Related Research Projects (R24)
Project #
5R24EY014793-05
Application #
7225942
Study Section
Special Emphasis Panel (ZEY1-VSN (08))
Program Officer
Chin, Hemin R
Project Start
2003-05-01
Project End
2009-04-30
Budget Start
2007-05-01
Budget End
2009-04-30
Support Year
5
Fiscal Year
2007
Total Cost
$198,478
Indirect Cost
Name
Medical University of South Carolina
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
183710748
City
Charleston
State
SC
Country
United States
Zip Code
29425
Trivedi, Rupal H; Wilson, M Edward (2013) Selection of an initial contact lens power for infantile cataract surgery without primary intraocular lens implantation. Ophthalmology 120:1973-6
Boyer, Nicholas P; Higbee, Daniel; Currin, Mark B et al. (2012) Lipofuscin and N-retinylidene-N-retinylethanolamine (A2E) accumulate in retinal pigment epithelium in absence of light exposure: their origin is 11-cis-retinal. J Biol Chem 287:22276-86
Wilson, M Edward; Hennig, Albrecht; Trivedi, Rupal H et al. (2011) Clinical characteristics and early postoperative outcomes of pediatric cataract surgery with IOL implantation from Lahan, Nepal. J Pediatr Ophthalmol Strabismus 48:286-91
Trivedi, Rupal H; Wilson, M Edward (2011) Axial length measurements by contact and immersion techniques in pediatric eyes with cataract. Ophthalmology 118:498-502
Vasavada, Abhay R; Shah, Sajani K; Praveen, Mamidipudi R et al. (2011) Pars plicata posterior continuous curvilinear capsulorhexis. J Cataract Refract Surg 37:221-3
Li, Xia; Li, Wensheng; Dai, Xufeng et al. (2011) Gene therapy rescues cone structure and function in the 3-month-old rd12 mouse: a model for midcourse RPE65 leber congenital amaurosis. Invest Ophthalmol Vis Sci 52:7-15
Abdel-Hafez, Ghada; Trivedi, Rupal H; Wilson, M Edward et al. (2011) Comparison of aphakic refraction formulas for secondary in-the-bag intraocular lens power estimation in children. J AAPOS 15:432-4
Truscott, Roger J W; Comte-Walters, Susana; Ablonczy, Zsolt et al. (2011) Tight binding of proteins to membranes from older human cells. Age (Dordr) 33:543-54
Grey, Angus C; Crouch, Rosalie K; Koutalos, Yiannis et al. (2011) Spatial localization of A2E in the retinal pigment epithelium. Invest Ophthalmol Vis Sci 52:3926-33
Gochnauer, Ashley C; Trivedi, Rupal H; Hill, Elizabeth G et al. (2010) Interocular axial length difference as a predictor of postoperative visual acuity after unilateral pediatric cataract extraction with primary IOL implantation. J AAPOS 14:20-4

Showing the most recent 10 out of 147 publications