Abstract

Nonhuman primates serve as crucial animal models for exploring the pathogenesis of infectious and noninfectious diseases, and for testing of new therapies and vaccines that cannot be evaluated in small animal models. This grant established the Nonhuman Primate Reagent Resource, a program for developing, manufacturing and distributing antibody-based reagents that deplete specific lymphocyte subpopulations or target specific immune functions in vivo. These novel reagents serve to optimize the use of nonhuman primates across multiple scientific disciplines. We will continue to serve as a resource laboratory, and take advantage of scientific advances and technological improvements by expanding the number and type of reagents we make available to biomedical investigators.

Public Health Relevance

The Nonhuman Primate Reagent Resource develops, manufactures and distributes antibody research reagents for use as tools in nonhuman primate models of disease. These antibody tools help investigators to develop treatments and vaccines for many different infectious diseases. Some antibodies are also being evaluated as therapeutics for autoimmune diseases and in organ transplantation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Office of The Director, National Institutes of Health (OD)
Type
Resource-Related Research Projects (R24)
Project #
5R24OD010976-18
Application #
9391148
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Watson, Harold L
Project Start
2000-09-01
Project End
2019-11-30
Budget Start
2017-12-01
Budget End
2018-11-30
Support Year
18
Fiscal Year
2018
Total Cost
Indirect Cost

  Institution

Name
University of Massachusetts Medical School Worcester
Department
Type
Overall Medical
DUNS #
603847393
City
Worcester
State
MA
Country
United States
Zip Code

  Publications

Santangelo, P J; Cicala, C; Byrareddy, S N et al. (2018) Early treatment of SIV+ macaques with an ?4?7 mAb alters virus distribution and preserves CD4+ T cells in later stages of infection. Mucosal Immunol 11:932-946
Calenda, Giulia; Keawvichit, Rassamon; Arrode-Brusés, Géraldine et al. (2018) Integrin ?4?7 Blockade Preferentially Impacts CCR6+ Lymphocyte Subsets in Blood and Mucosal Tissues of Naive Rhesus Macaques. J Immunol 200:810-820
Lim, So-Yon; Osuna, Christa E; Hraber, Peter T et al. (2018) TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy. Sci Transl Med 10:
Zhang, Tianshu; Azimzadeh, Agnes M; Sun, Wenji et al. (2018) Selective CD28 Inhibition Modulates Alloimmunity and Cardiac Allograft Vasculopathy in Anti-CD154-Treated Monkeys. Transplantation 102:e90-e100
Min, Byoung-Hoon; Shin, Jun-Seop; Kim, Jong-Min et al. (2018) Delayed revascularization of islets after transplantation by IL-6 blockade in pig to non-human primate islet xenotransplantation model. Xenotransplantation 25:
Hotta, Kiyohiko; Oura, Tetsu; Dehnadi, Abbas et al. (2018) Long-term Nonhuman Primate Renal Allograft Survival Without Ongoing Immunosuppression in Recipients of Delayed Donor Bone Marrow Transplantation. Transplantation 102:e128-e136
Nawaz, Fatima; Goes, Livia R; Ray, Jocelyn C et al. (2018) MAdCAM costimulation through Integrin-?4?7 promotes HIV replication. Mucosal Immunol 11:1342-1351
O'Neill, Natalie A; Zhang, Tianshu; Braileanu, Gheorghe et al. (2018) Pilot Study of Delayed ICOS/ICOS-L Blockade With ?CD40 to Modulate Pathogenic Alloimmunity in a Primate Cardiac Allograft Model. Transplant Direct 4:e344
Choi, Se Hyun; Yoon, Chang Ho; Lee, Hyun Ju et al. (2018) Long-term safety outcome of systemic immunosuppression in pig-to-nonhuman primate corneal xenotransplantation. Xenotransplantation 25:e12442
Shin, Jun-Seop; Kim, Jong-Min; Min, Byoung-Hoon et al. (2018) Pre-clinical results in pig-to-non-human primate islet xenotransplantation using anti-CD40 antibody (2C10R4)-based immunosuppression. Xenotransplantation 25:

Showing the most recent 10 out of 57 publications