! ! This application requests funding for the renewal of our NIDA-funded one-year intensive addiction research training fellowship for addiction medicine clinicians. Despite the enormous burden of disease attributable to drug and alcohol addiction, there remain major challenges in implementing evidence-based prevention and treatment modalities for substance use disorders. Low levels of understanding of addiction science among addiction care providers also creates barriers to the implementation of evidence-based public health programs. The unprecedented rise in opioid overdose deaths in North America and HIV outbreaks linked to the opioid epidemic in several regions underscore a pressing need to bridge the evidence-to-practice gap as critical to the response. This provides the rationale for our fellowship program and our desire to extend and expand our fellowship program, already proven to be highly successful at training a substantial number of highly productive young clinician scientists. The International Collaborative Addiction Medicine Research Fellowship provides a flexible, well-established learning environment with a multidisciplinary and international team of 21 highly productive researchers who are committed to training the next generation of addiction clinician scientists. It builds upon a well-established NIDA-funded research infrastructure involving evaluation of unique interventions being implemented in the context of a severe local fentanyl-related opioid epidemic. Furthermore, the fellowship provides addiction medicine clinicians with research methods training, education in the ethical conduct of research, peer-reviewed publication and funding proposal development, presentation skills, and career development training critical for designing and conducting studies on substance use disorders and related comorbidities, including the prevention and treatment of HIV among substance users. Finally, the fellowship includes the continuation of a rigorous prospective evaluation showing how a dedicated research training program for addiction medicine physicians contributes to subsequent ongoing research involvement and research productivity among the next generation of clinician scientists working in the area of substance use disorders. The fellowship has already proven to be well-received and highly successful (as measured by candidates' first-author publications) over the past four years, and the resources and range of clinical trials and educational activities have expanded significantly since the initiation of this addiction medicine fellowship program in 2014. With a growing network of highly regarded interdisciplinary researchers in various fields of addiction medicine with whom fellows can work, we are excited about the possibility of renewing this fellowship so that it can continue to expand the delivery of evidence-based treatment in the field of addiction medicine. This proposal responds directly to the US National Institute on Drug Abuse's expressed ?strong interest in supporting the development of clinical research expertise internationally.? Accordingly, the work proposed herein is strongly aligned with the NIDA International Program's call for research education for addiction medicine physicians.

Public Health Relevance

The enormous burden of disease related to drug and alcohol addiction remains a global public health challenge. In particular, the lack of clinician researchers in addiction medicine creates major barriers to developing and implementing evidence-based prevention and treatment modalities for substance use disorders. In response, we have created a NIDA-funded addiction research training fellowship for addiction medicine clinicians to develop the skills required for a career in addiction research, and we are proposing the renewal of this program in light of its success to date.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Education Projects (R25)
Project #
2R25DA037756-06A1
Application #
9779268
Study Section
Special Emphasis Panel (ZDA1)
Program Officer
Wiley, Tisha R A
Project Start
2014-04-01
Project End
2024-04-30
Budget Start
2019-05-01
Budget End
2020-04-30
Support Year
6
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of British Columbia
Department
Type
DUNS #
251949962
City
Vancouver
State
BC
Country
Canada
Zip Code
V6 1Z3
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Klimas, Jan; Nosova, Ekaterina; Socías, Eugenia et al. (2018) Factors associated with discontinuation of methadone maintenance therapy (MMT) among persons who use alcohol in Vancouver, Canada. Drug Alcohol Depend 186:182-186
Chang, Derek C; Rieb, Launette; Nosova, Ekaterina et al. (2018) Hospitalization among street-involved youth who use illicit drugs in Vancouver, Canada: a longitudinal analysis. Harm Reduct J 15:14
Chang, Derek C; Klimas, Jan; Wood, Evan et al. (2018) A Case of Opioid Overdose and Subsequent Death After Medically Supervised Withdrawal: The Problematic Role of Rapid Tapers for Opioid Use Disorder. J Addict Med 12:80-83
Socías, M Eugenia; Wood, Evan (2018) Evaluating Slow-Release Oral Morphine to Narrow the Treatment Gap for Opioid Use Disorders. Ann Intern Med 168:141-142
Hill, Megan; Vipler, Sharon; Sutherland, Christy et al. (2018) Challenges of treatment of acutely ill patients enrolled in a managed alcohol program. Drug Alcohol Rev 37 Suppl 1:S143-S144
Chang, Derek C; Klimas, Jan; Wood, Evan et al. (2018) Medication-assisted treatment for youth with opioid use disorder: Current dilemmas and remaining questions. Am J Drug Alcohol Abuse 44:143-146
Baldwin, Nicholas; Gray, Roger; Goel, Anirudh et al. (2018) Fentanyl and heroin contained in seized illicit drugs and overdose-related deaths in British Columbia, Canada: An observational analysis. Drug Alcohol Depend 185:322-327
Klimas, Jan; Dong, Huiru; Fairbairn, Nadia et al. (2018) Eligibility for heroin-assisted treatment (HAT) among people who inject opioids and are living with HIV in a Canadian setting. Addict Sci Clin Pract 13:3
Reddon, Hudson; Ho, Joel; DeBeck, Kora et al. (2018) Increasing diversion of methadone in Vancouver, Canada, 2005-2015. J Subst Abuse Treat 85:10-16

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