Sample-size planning is currently the Achilles heel of biomedical research. Many fields of preclinical research routinely rely on inadequate samples, leading to waste, excessive false-positives, and inflated effect sizes. These practices persist because researchers often eschew sound sample-size planning for easy but invalid approaches. To help address this critical issue, this project will produce a self-guided online course that will help trainees exchange poor sample-size determination practices for sound approaches. The course will a) help redirect researchers away from erroneous approaches by making clear their severe negative consequences, b) will dispel common misconceptions that discourage sound sample-size planning, and c) will provide exercises with instant feedback to build self-efficacy for independent sample-size planning. The materials will be produced for a modest budget, will incorporate guidance from a team of renowned methodological experts, and will be anchored in a proven behavioral-change approach. The course will provide a needed supplement to current materials, which do not adequately teach sample-size determination. A thoughtful piloting plan will enable extensive feedback from diverse stakeholders to ensure strong impact not only on knowledge but also on attitudes and actual competency. Dissemination will be supported through partnerships with professional societies and the extensive social media reach of the participating guest lecturers. Funding this proposal can have a strong positive impact on rigor and reproducibility in preclinical research.

Public Health Relevance

The goal of this project is to develop an autonomous, open-access online course on sample-size determination for preclinical researcher. Currently, many researchers rely on inadequate samples, a practice which leads to waste, false-positives, and unreproducible results. This course will help researchers adopt valid sample-size planning approaches, providing direct benefits to the quality and reproducibility of NIH-funded pre-clinical research.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Education Projects (R25)
Project #
5R25GM132784-02
Application #
9925089
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Zuk, Dorit
Project Start
2019-05-01
Project End
2021-04-30
Budget Start
2020-05-01
Budget End
2021-04-30
Support Year
2
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Dominican University
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
064390230
City
River Forest
State
IL
Country
United States
Zip Code
60305