There is a marked gap between our ability to treat neurologic diseases and our rapidly increasing understanding of normal nervous system function, disease pathogenesis, and disease pathophysiology. Improving treatment of neurologic diseases requires considerably improved integration of burgeoning basic neuroscience with clinical practice across the translational spectrum from basic discovery through preclinical and clinical research to implementation. An obstacle to improved integration of disease-oriented neuroscience research activities and more efficient translation is a deficit of appropriately trained clinician-neuroscientists. American medical schools graduate significant numbers of physicians with substantial research experience, including MD/PhDs and individuals with significant experience with and formal training in clinical and policy research. The traditionl clinical training structure, however, impedes the ability of these talented and well trained individuals to efficiently initiate productive, independent research careers. We propose a residency- fellowship based training program integrating residency-fellowship based clinical training with mentored research training to move talented and experienced trainees in Neurology, Neurosurgery, and Neuropathology to the initial stage of an independent career. The goal of the University of Michigan Clinical Neuroscientist Training Program (UMCNTP) is prepare talented clinician-neuroscientists for independent research careers across the full spectrum of disease-oriented neuroscience research. The UMCNTP is an integrated residency- fellowship program to prepare talented fledgling clinician-neuroscientists for successful applications for initial independent career support. The UMCNTP melds productive mentored research experience under the guidance of experienced senior investigators with focused didactic and hands-on career training to prepare UMCNTP trainees for successful career development applications such as K08, K23, VA CDA, or equivalents. The UMCNTP features a strong roster of mentors in the Depts. of Neurology, Neurosurgery, and Pathology, a training program based on highly successful prior experiences with training clinician-neuroscientists, utilizes excellent career development resources available at the University of Michigan, and draws on the great diversity and general excellence of the Neuroscience research community of the University of Michigan.

Public Health Relevance

Clinician-neuroscientists bring indispensable skills to disease-oriented research and facilitate the integration of research and clinical practice. This program will improve the supply of clinician-neuroscientists starting independent research careers.

Agency
National Institute of Health (NIH)
Institute
National Institute of Neurological Disorders and Stroke (NINDS)
Type
Education Projects (R25)
Project #
5R25NS089450-05
Application #
9501790
Study Section
Special Emphasis Panel (ZNS1)
Program Officer
Korn, Stephen J
Project Start
2014-08-01
Project End
2019-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
5
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Neurology
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
McGinley, Lisa M; Kashlan, Osama N; Chen, Kevin S et al. (2017) Human neural stem cell transplantation into the corpus callosum of Alzheimer's mice. Ann Clin Transl Neurol 4:749-755
Chen, Kevin S; McIntyre, Jeremy C; Lieberman, Andrew P et al. (2016) Human spinal autografts of olfactory epithelial stem cells recapitulate donor site histology, maintaining proliferative and differentiation capacity many years after transplantation. Acta Neuropathol 131:639-40
McGinley, Lisa M; Sims, Erika; Lunn, J Simon et al. (2016) Human Cortical Neural Stem Cells Expressing Insulin-Like Growth Factor-I: A Novel Cellular Therapy for Alzheimer's Disease. Stem Cells Transl Med 5:379-91
Chen, Kevin S; Sakowski, Stacey A; Feldman, Eva L (2016) Intraspinal stem cell transplantation for amyotrophic lateral sclerosis. Ann Neurol 79:342-53
Goutman, Stephen A; Chen, Kevin S; Feldman, Eva L (2015) Recent Advances and the Future of Stem Cell Therapies in Amyotrophic Lateral Sclerosis. Neurotherapeutics 12:428-48
Callaghan, Brian C; Price, Raymond S; Chen, Kevin S et al. (2015) The Importance of Rare Subtypes in Diagnosis and Treatment of Peripheral Neuropathy: A Review. JAMA Neurol 72:1510-8