Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29AI027461-01
Application #
3455009
Study Section
Tropical Medicine and Parasitology Study Section (TMP)
Project Start
1988-12-01
Project End
1993-11-30
Budget Start
1988-12-01
Budget End
1989-11-30
Support Year
1
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Heinzel, F P; Rerko, R M; Ling, P et al. (1994) Interleukin 12 is produced in vivo during endotoxemia and stimulates synthesis of gamma interferon. Infect Immun 62:4244-9
Heinzel, F P; Schoenhaut, D S; Rerko, R M et al. (1993) Recombinant interleukin 12 cures mice infected with Leishmania major. J Exp Med 177:1505-9
Heinzel, F P; Rerko, R M; Hatam, F et al. (1993) IL-2 is necessary for the progression of leishmaniasis in susceptible murine hosts. J Immunol 150:3924-31
Locksley, R M; Heinzel, F P; Holaday, B J et al. (1991) Induction of Th1 and Th2 CD4+ subsets during murine Leishmania major infection. Res Immunol 142:28-32
Heinzel, F P; Sadick, M D; Mutha, S S et al. (1991) Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis. Proc Natl Acad Sci U S A 88:7011-5
Holaday, B J; Sadick, M D; Wang, Z E et al. (1991) Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cell lines. J Immunol 147:1653-8
Gibbons, R; Martinez, O; Matli, M et al. (1990) Recombinant IL-4 inhibits IL-6 synthesis by adherent peripheral blood cells in vitro. Lymphokine Res 9:283-93
Heinzel, F P (1990) The role of IFN-gamma in the pathology of experimental endotoxemia. J Immunol 145:2920-4
Sadick, M D; Heinzel, F P; Holaday, B J et al. (1990) Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody. Evidence for a T cell-dependent, interferon gamma-independent mechanism. J Exp Med 171:115-27