Molecular Genetic Analysis of Salmonella Cell Invasion

Galan, Jorge E.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: First Independent Research Support & Transition (FIRST) Awards (R29)
• Project #: 3R29AI030492-02S1
• Application #: 3455682
• Study Section: Bacteriology and Mycology Subcommittee 2 (BM)
• Project Start: 1992-09-01
• Project End: 1995-12-31
• Budget Start: 1992-09-01
• Budget End: 1992-12-31
• Support Year: 2
• Fiscal Year: 1992

Institution

• Name: State University New York Stony Brook
• Type: Schools of Medicine
• DUNS #: 804878247
• City: Stony Brook
• State: NY
• Country: United States
• Zip Code: 11794

Publications

Tsou, Lun K; Lara-Tejero, María; RoseFigura, Jordan et al. (2016) Antibacterial Flavonoids from Medicinal Plants Covalently Inactivate Type III Protein Secretion Substrates. J Am Chem Soc 138:2209-18

Monjarás Feria, Julia V; Lefebre, Matthew D; Stierhof, York-Dieter et al. (2015) Role of autocleavage in the function of a type III secretion specificity switch protein in Salmonella enterica serovar Typhimurium. MBio 6:e01459-15

Kato, Junya; Lefebre, Matthew; Galán, Jorge E (2015) Structural Features Reminiscent of ATP-Driven Protein Translocases Are Essential for the Function of a Type III Secretion-Associated ATPase. J Bacteriol 197:3007-14

Lefebre, Matthew D; Galán, Jorge E (2014) The inner rod protein controls substrate switching and needle length in a Salmonella type III secretion system. Proc Natl Acad Sci U S A 111:817-22

Rathinavelan, Thenmalarchelvi; Lara-Tejero, Maria; Lefebre, Matthew et al. (2014) NMR model of PrgI-SipD interaction and its implications in the needle-tip assembly of the Salmonella type III secretion system. J Mol Biol 426:2958-69

Galán, Jorge E; Lara-Tejero, Maria; Marlovits, Thomas C et al. (2014) Bacterial type III secretion systems: specialized nanomachines for protein delivery into target cells. Annu Rev Microbiol 68:415-38

Carleton, Heather A; Lara-Tejero, Maria; Liu, Xiaoyun et al. (2013) Engineering the type III secretion system in non-replicating bacterial minicells for antigen delivery. Nat Commun 4:1590

Zhong, Dalian; Lefebre, Matthew; Kaur, Kawaljit et al. (2012) The Salmonella type III secretion system inner rod protein PrgJ is partially folded. J Biol Chem 287:25303-11

Button, Julie E; Galan, Jorge E (2011) Regulation of chaperone/effector complex synthesis in a bacterial type III secretion system. Mol Microbiol 81:1474-83

Lara-Tejero, Maria; Kato, Junya; Wagner, Samuel et al. (2011) A sorting platform determines the order of protein secretion in bacterial type III systems. Science 331:1188-91