The investigator proposes to study cis-acting viral and trans-acting cellular factors which regulate transcription of HIV-2. The goal is to attempt to understand the role of cellular transcription factors in the replication of the virus. The applicant has three specific aims, the first of which is to try to characterize NF-CD3R and the mechanism by which it activates the HIV-2 enhancer. The second goal of the project is to attempt to identify cDNA clones encoding proteins which bind to the CD3R site. Lastly, the applicant proposes to determine the role of NF-CD3R in viral replication in different cell types.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29AI030924-03
Application #
3455747
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Project Start
1991-06-01
Project End
1996-05-31
Budget Start
1993-06-01
Budget End
1994-05-31
Support Year
3
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109