Abstract

Simian immunodeficiency virus (SIV) infection of macaque monkeys is an important model for the study of AIDS. The nucleotide sequence similarities to HIV and ability to induce AIDS in macaques make SIVs and their infection of these monkeys particularly important models for the development of AIDS vaccine strategies. In investigating the immune response to SIV in macaques, it will be important therefore to define the genes and gene products of the macaque's MHC. The investigator will therefore first characterize the MHC genes and gene products of the rhesus monkey and, and second explore the possible relationships between certain MHC haplotypes and length of survival after SIV infection in this species.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29AI032426-04
Application #
2067307
Study Section
AIDS and Related Research Study Section 1 (ARRA)
Project Start
1992-03-01
Project End
1997-02-28
Budget Start
1994-03-01
Budget End
1995-02-28
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Veterinary Sciences
Type
Other Domestic Higher Education
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Evans, D T; Jing, P; Allen, T M et al. (2000) Definition of five new simian immunodeficiency virus cytotoxic T-lymphocyte epitopes and their restricting major histocompatibility complex class I molecules: evidence for an influence on disease progression. J Virol 74:7400-10
Boyson, J E; Iwanaga, K K; Urvater, J A et al. (1999) Evolution of a new nonclassical MHC class I locus in two Old World primate species. Immunogenetics 49:86-98
Evans, D T; O'Connor, D H; Jing, P et al. (1999) Virus-specific cytotoxic T-lymphocyte responses select for amino-acid variation in simian immunodeficiency virus Env and Nef. Nat Med 5:1270-6
Vogel, T U; Evans, D T; Urvater, J A et al. (1999) Major histocompatibility complex class I genes in primates: co-evolution with pathogens. Immunol Rev 167:327-37
Hanke, T; Samuel, R V; Blanchard, T J et al. (1999) Effective induction of simian immunodeficiency virus-specific cytotoxic T lymphocytes in macaques by using a multiepitope gene and DNA prime-modified vaccinia virus Ankara boost vaccination regimen. J Virol 73:7524-32
Evans, D T; Knapp, L A; Jing, P et al. (1999) Rapid and slow progressors differ by a single MHC class I haplotype in a family of MHC-defined rhesus macaques infected with SIV. Immunol Lett 66:53-9
Allen, T M; Sidney, J; del Guercio, M F et al. (1998) Characterization of the peptide binding motif of a rhesus MHC class I molecule (Mamu-A*01) that binds an immunodominant CTL epitope from simian immunodeficiency virus. J Immunol 160:6062-71
Slukvin, I I; Boyson, J E; Watkins, D I et al. (1998) The rhesus monkey analogue of human lymphocyte antigen-G is expressed primarily in villous syncytiotrophoblasts. Biol Reprod 58:728-38
Knapp, L A; Cadavid, L F; Eberle, M E et al. (1997) Identification of new mamu-DRB alleles using DGGE and direct sequencing. Immunogenetics 45:171-9
Knapp, L A; Lehmann, E; Piekarczyk, M S et al. (1997) A high frequency of Mamu-A*01 in the rhesus macaque detected by polymerase chain reaction with sequence-specific primers and direct sequencing. Tissue Antigens 50:657-61

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