Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29AI033110-05
Application #
2068102
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1992-07-01
Project End
1997-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Rhode Island Hospital (Providence, RI)
Department
Type
DUNS #
161202122
City
Providence
State
RI
Country
United States
Zip Code
02903
Simms, H H; D'Amico, R (1997) Posttraumatic auto-oxidative polymorphonuclear neutrophil receptor injury predicts the development of nosocomial infection. Arch Surg 132:171-7
Knowles, R; Keeping, H; Graeber, T et al. (1997) Cytokine control of PMN phagocytosis: regulatory effects of hypoxemia and hypoxemia-reoxygenation. Am J Physiol 272:C1352-64
Simms, H; D'Amico, R (1996) Regulation of polymorphonuclear leukocyte cytokine receptor expression: the role of altered oxygen tensions and matrix proteins. J Immunol 157:3605-16
Simms, H; D'Amico, R; Garner, C (1996) Polymorphonuclear leukocyte opsonic receptor expression after hypoxia/reoxygenation. J Lab Clin Med 127:364-81
Derevianko, A; Graeber, T; D'Amico, R et al. (1996) Altered oxygen tension modulates cytokine-induced signal transduction in polymorphonuclear leukocytes: regulation of the G PLC pathway. J Surg Res 62:32-40
Simms, H H; D'Amico, R (1995) Subcellular location of neutrophil opsonic receptors is altered by exogenous reactive oxygen species. Cell Immunol 166:71-82
Simms, H H; D'Amico, R (1995) Lipopolysaccharide induces intracytoplasmic migration of the polymorphonuclear leukocyte CD11b/CD18 receptor. Shock 3:196-203
Simms, H; D'Amico, R (1995) Regulation of polymorphonuclear neutrophil CD16 and CD11b/CD18 expression by matrix proteins during hypoxia is VLA-5, VLA-6 dependent. J Immunol 155:4979-90
Knowles, R; Keeping, H; Nguyen, K et al. (1995) Hypoxemia up-regulates interleukin-8 stimulated phagocytosis of polymorphonuclear leukocytes by differential regulation of CD32w and CD35 messenger RNA expression. Surgery 118:177-83;discussion 183-4
Simms, H H; D'Amico, R (1994) Polymorphonuclear leukocyte dysregulation during the systemic inflammatory response syndrome. Blood 83:1398-407

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