Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29AI033325-05
Application #
2068322
Study Section
AIDS and Related Research Study Section 5 (ARRE)
Project Start
1992-07-01
Project End
1998-04-30
Budget Start
1996-05-01
Budget End
1998-04-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Dartmouth College
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Bhadra, Rajarshi; Cobb, Dustin A; Weiss, Louis M et al. (2013) Psychiatric disorders in toxoplasma seropositive patients--the CD8 connection. Schizophr Bull 39:485-9
Bhadra, Rajarshi; Cobb, Dustin A; Khan, Imtiaz A (2013) Donor CD8+ T cells prevent Toxoplasma gondii de-encystation but fail to rescue the exhausted endogenous CD8+ T cell population. Infect Immun 81:3414-25
Bhadra, Rajarshi; Cobb, Dustin A; Khan, Imtiaz A (2013) CD40 signaling to the rescue: A CD8 exhaustion perspective in chronic infectious diseases. Crit Rev Immunol 33:361-78
Bhadra, Rajarshi; Khan, Imtiaz A (2012) Redefining chronic toxoplasmosis--a T cell exhaustion perspective. PLoS Pathog 8:e1002903
Gigley, Jason P; Bhadra, Rajarshi; Moretto, Magali M et al. (2012) T cell exhaustion in protozoan disease. Trends Parasitol 28:377-84
Bhadra, Rajarshi; Khan, Imtiaz A (2012) IL-7 and IL-15 do not synergize during CD8 T cell recall response against an obligate intracellular parasite. Microbes Infect 14:1160-8
Bhadra, Rajarshi; Gigley, Jason P; Khan, Imtiaz A (2012) PD-1-mediated attrition of polyfunctional memory CD8+ T cells in chronic toxoplasma infection. J Infect Dis 206:125-34
Bhadra, Rajarshi; Gigley, Jason P; Weiss, Louis M et al. (2011) Control of Toxoplasma reactivation by rescue of dysfunctional CD8+ T-cell response via PD-1-PDL-1 blockade. Proc Natl Acad Sci U S A 108:9196-201
Bhadra, Rajarshi; Gigley, Jason P; Khan, Imtiaz A (2011) The CD8 T-cell road to immunotherapy of toxoplasmosis. Immunotherapy 3:789-801
Bhadra, Rajarshi; Gigley, Jason P; Khan, Imtiaz A (2011) Cutting edge: CD40-CD40 ligand pathway plays a critical CD8-intrinsic and -extrinsic role during rescue of exhausted CD8 T cells. J Immunol 187:4421-5

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