Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29AI034051-04
Application #
2069138
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1993-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Alexander, J E; Berry, A M; Paton, J C et al. (1998) Amino acid changes affecting the activity of pneumolysin alter the behaviour of pneumococci in pneumonia. Microb Pathog 24:167-74
Rubins, J B; Puri, A K; Loch, J et al. (1998) Magnitude, duration, quality, and function of pneumococcal vaccine responses in elderly adults. J Infect Dis 178:431-40
Rubins, J B; Greatens, T; Kratzke, R A et al. (1998) Lovastatin induces apoptosis in malignant mesothelioma cells. Am J Respir Crit Care Med 157:1616-22
Greatens, T M; Niehans, G A; Rubins, J B et al. (1998) Do molecular markers predict survival in non-small-cell lung cancer? Am J Respir Crit Care Med 157:1093-7
Rubins, J B; Pomeroy, C (1997) Role of gamma interferon in the pathogenesis of bacteremic pneumococcal pneumonia. Infect Immun 65:2975-7
Rubins, J B; Charboneau, D; Prigge, W et al. (1996) Ethanol ingestion reduces antipneumococcal activity of rat pulmonary surfactant. J Infect Dis 174:507-12
Rubins, J B; Charboneau, D; Fasching, C et al. (1996) Distinct roles for pneumolysin's cytotoxic and complement activities in the pathogenesis of pneumococcal pneumonia. Am J Respir Crit Care Med 153:1339-46
Rubins, J B; Charboneau, D; Paton, J C et al. (1995) Dual function of pneumolysin in the early pathogenesis of murine pneumococcal pneumonia. J Clin Invest 95:142-50
Amdahl, B M; Rubins, J B; Daley, C L et al. (1995) Impaired natural immunity to pneumolysin during human immunodeficiency virus infection in the United States and Africa. Am J Respir Crit Care Med 152:2000-4
Rubins, J B; Mitchell, T J; Andrew, P W et al. (1994) Pneumolysin activates phospholipase A in pulmonary artery endothelial cells. Infect Immun 62:3829-36

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