Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29AI039001-01
Application #
2076113
Study Section
Bacteriology and Mycology Subcommittee 2 (BM)
Project Start
1996-09-15
Project End
2001-08-31
Budget Start
1996-09-15
Budget End
1997-08-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
City
Torrance
State
CA
Country
United States
Zip Code
90502
Sakoulas, George; Okumura, Cheryl Y; Thienphrapa, Wdee et al. (2014) Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureus. J Mol Med (Berl) 92:139-49
Yang, Soo-Jin; Xiong, Yan Q; Yeaman, Michael R et al. (2013) Role of the LytSR two-component regulatory system in adaptation to cationic antimicrobial peptides in Staphylococcus aureus. Antimicrob Agents Chemother 57:3875-82
Mishra, Nagendra N; Yang, Soo-Jin; Chen, Liang et al. (2013) Emergence of daptomycin resistance in daptomycin-naïve rabbits with methicillin-resistant Staphylococcus aureus prosthetic joint infection is associated with resistance to host defense cationic peptides and mprF polymorphisms. PLoS One 8:e71151
Yang, Soo-Jin; Bayer, Arnold S; Mishra, Nagendra N et al. (2012) The Staphylococcus aureus two-component regulatory system, GraRS, senses and confers resistance to selected cationic antimicrobial peptides. Infect Immun 80:74-81
Bertsche, Ute; Weidenmaier, Christopher; Kuehner, Daniel et al. (2011) Correlation of daptomycin resistance in a clinical Staphylococcus aureus strain with increased cell wall teichoic acid production and D-alanylation. Antimicrob Agents Chemother 55:3922-8
Mishra, Nagendra N; Liu, George Y; Yeaman, Michael R et al. (2011) Carotenoid-related alteration of cell membrane fluidity impacts Staphylococcus aureus susceptibility to host defense peptides. Antimicrob Agents Chemother 55:526-31
Mishra, Nagendra N; McKinnell, James; Yeaman, Michael R et al. (2011) In vitro cross-resistance to daptomycin and host defense cationic antimicrobial peptides in clinical methicillin-resistant Staphylococcus aureus isolates. Antimicrob Agents Chemother 55:4012-8
Yount, Nannette Y; Cohen, Samuel E; Kupferwasser, Deborah et al. (2011) Context mediates antimicrobial efficacy of kinocidin congener peptide RP-1. PLoS One 6:e26727
Seidl, Kati; Bayer, Arnold S; Fowler Jr, Vance G et al. (2011) Combinatorial phenotypic signatures distinguish persistent from resolving methicillin-resistant Staphylococcus aureus bacteremia isolates. Antimicrob Agents Chemother 55:575-82
Yang, Soo-Jin; Nast, Cynthia C; Mishra, Nagendra N et al. (2010) Cell wall thickening is not a universal accompaniment of the daptomycin nonsusceptibility phenotype in Staphylococcus aureus: evidence for multiple resistance mechanisms. Antimicrob Agents Chemother 54:3079-85

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