Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29AI040135-01
Application #
2077052
Study Section
Special Emphasis Panel (ZRG2-ALY (01))
Project Start
1996-06-01
Project End
2001-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Ulrichs, T; Porcelli, S A (2000) CD1 proteins: targets of T cell recognition in innate and adaptive immunity. Rev Immunogenet 2:416-32
Briken, V; Jackman, R M; Watts, G F et al. (2000) Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens. J Exp Med 192:281-8
Melian, A; Watts, G F; Shamshiev, A et al. (2000) Molecular recognition of human CD1b antigen complexes: evidence for a common pattern of interaction with alpha beta TCRs. J Immunol 165:4494-504
Spada, F M; Borriello, F; Sugita, M et al. (2000) Low expression level but potent antigen presenting function of CD1d on monocyte lineage cells. Eur J Immunol 30:3468-77
Moody, D B; Guy, M R; Grant, E et al. (2000) CD1b-mediated T cell recognition of a glycolipid antigen generated from mycobacterial lipid and host carbohydrate during infection. J Exp Med 192:965-76
Moody, D B; Reinhold, B B; Reinhold, V N et al. (1999) Uptake and processing of glycosylated mycolates for presentation to CD1b-restricted T cells. Immunol Lett 65:85-91
Jackman, R M; Moody, D B; Porcelli, S A (1999) Mechanisms of lipid antigen presentation by CD1. Crit Rev Immunol 19:49-63
Moody, D B; Besra, G S; Wilson, I A et al. (1999) The molecular basis of CD1-mediated presentation of lipid antigens. Immunol Rev 172:285-96
Melian, A; Geng, Y J; Sukhova, G K et al. (1999) CD1 expression in human atherosclerosis. A potential mechanism for T cell activation by foam cells. Am J Pathol 155:775-86
Exley, M; Porcelli, S; Furman, M et al. (1998) CD161 (NKR-P1A) costimulation of CD1d-dependent activation of human T cells expressing invariant V alpha 24 J alpha Q T cell receptor alpha chains. J Exp Med 188:867-76

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