Abstract

The goal of this application is to identify the molecular mechanisms of perinatal HIV-1 transmission with the aim of developing relevant strategies for prevention. The investigator posits that there are specific molecular and biological properties of HIV-1 that include the functional domains in the gp120 region of Env and the p17 region of Gag that are critical determinants of perinatal HIV-1 transmission. Hypothesis-driven studies are proposed to; determine the molecular properties of viruses transmitted from an infected mother to her infant, identify and characterize the viral determinants associated with perinatal HIV-1 transmission, and determine the biological properties of viruses that are or are not transmitted from a mother to her infant.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29AI040378-03
Application #
2887309
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Program Officer
Hoff, Rodney
Project Start
1997-04-01
Project End
2002-03-31
Budget Start
1999-04-01
Budget End
2000-03-31
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
University of Arizona
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
Tucson
State
AZ
Country
United States
Zip Code
85721