Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29AI040768-01
Application #
2077274
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1996-07-01
Project End
2001-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Medical College of Wisconsin
Department
Dermatology
Type
Schools of Medicine
DUNS #
073134603
City
Milwaukee
State
WI
Country
United States
Zip Code
53226
Evangelista, Flor; Roth, Aleeza J; Prisayanh, Phillip et al. (2018) Pathogenic IgG4 autoantibodies from endemic pemphigus foliaceus recognize a desmoglein-1 conformational epitope. J Autoimmun 89:171-185
Zuo, Yagang; Evangelista, Flor; Culton, Donna et al. (2016) IgG4 autoantibodies are inhibitory in the autoimmune disease bullous pemphigoid. J Autoimmun 73:111-9
Lin, Lan; Betsuyaku, Tomoko; Heimbach, Lisa et al. (2012) Neutrophil elastase cleaves the murine hemidesmosomal protein BP180/type XVII collagen and generates degradation products that modulate experimental bullous pemphigoid. Matrix Biol 31:38-44
Heimbach, Lisa; Li, Zhuowei; Berkowitz, Paula et al. (2011) The C5a receptor on mast cells is critical for the autoimmune skin-blistering disease bullous pemphigoid. J Biol Chem 286:15003-9
Lin, Lan; Bankaitis, Eric; Heimbach, Lisa et al. (2011) Dual targets for mouse mast cell protease-4 in mediating tissue damage in experimental bullous pemphigoid. J Biol Chem 286:37358-67
Li, Ning; Park, Moonhee; Zhao, Minglang et al. (2010) The Thomsen-Friedenreich antigen-binding lectin jacalin interacts with desmoglein-1 and abrogates the pathogenicity of pemphigus foliaceus autoantibodies in vivo. J Invest Dermatol 130:2773-80
Olivry, Thierry; Dunston, Stanley M; Walker, Robina H et al. (2009) Investigations on the nature and pathogenicity of circulating antikeratinocyte antibodies in dogs with pemphigus foliaceus. Vet Dermatol 20:42-50
Heimbach, L; Li, N; Diaz, A et al. (2009) Experimental animal models of bullous pemphigoid. G Ital Dermatol Venereol 144:423-31
Li, Ning; Zhao, Minglang; Wang, Jinzhao et al. (2009) Involvement of the apoptotic mechanism in pemphigus foliaceus autoimmune injury of the skin. J Immunol 182:711-7
Chen, R; Ning, G; Zhao, M L et al. (2001) Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid. J Clin Invest 108:1151-8

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