The aim of this proposal is to facilitate the understanding of radiobiological phenomena to help optimize experimental designs and to give a rigorous basis for the implementation of radiobiological knowledge to radiotherapy through the development of mathematical models and statistical methods in the fields of radiotherapy and radiobiology. Nine projects will be described, all of which involve either mathematical modeling of radiobiological phenomena or the development of the most appropriate statistical techniques for the type of data that are collected in clinical and laboratory studies of radiation response. Many of the projects involve extensive use of computers. The nine projects, arranged in three groups, are: Clinical Studies: (i) analysis of a large, meticulously collected, data set on the response of radiotherapy patients with head and neck tumors, (ii) investigation of the """"""""shape"""""""" of dose- time curves for head and neck tumors, (iii) adaptation of some computer software to calculate biological isodoses in addition to physical isoeffective doses. Animal Experimental Studies: (iv) developing methods of analysis of late effect responses using the time to development of the effect as endpoint, (v) developing statistical methods to fit the linear-guadratic model to categorical ordered response data, (vi) design and analysis of top- up experiments, (vii) developing statistical methods for analyzing hair depigmentation data as an example for a general model for this type of radiobiological data, (viii) developing statistical methods for the analysis of overdispersed data in radiobiology. Experimental and Clinical Correlations: (ix) development of a mathematical model for regeneration in acutely-responding tissues. There is a wide spectrum of problems in radiation research which are amenable to mathematical approaches and a number of other projects are in various stages of development. The mathematical models will be developed and tested on a variety of data sets available to the investigators. Equally important, we have the facilities to apply the results of such modeling to experimental testing.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA045216-04
Application #
3458275
Study Section
Radiation Study Section (RAD)
Project Start
1988-09-01
Project End
1993-08-31
Budget Start
1991-09-01
Budget End
1992-08-31
Support Year
4
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Withers, H R; Peters, L J; Taylor, J M et al. (1995) Local control of carcinoma of the tonsil by radiation therapy: an analysis of patterns of fractionation in nine institutions. Int J Radiat Oncol Biol Phys 33:549-62
Withers, H R; Peters, L J; Taylor, J M et al. (1995) Late normal tissue sequelae from radiation therapy for carcinoma of the tonsil: patterns of fractionation study of radiobiology. Int J Radiat Oncol Biol Phys 33:563-8
Taylor, J M; Kim, D K (1993) Statistical models for analysing time-to-occurrence data in radiobiology and radiation oncology. Int J Radiat Biol 64:627-40
Lo, Y; Taylor, J M; McBride, W H et al. (1993) The effect of fractionated doses of radiation on mouse spinal cord. Int J Radiat Oncol Biol Phys 27:309-17
Withers, H R; Mason, K A; Taylor, J M et al. (1993) Dose-survival curves, alpha/beta ratios, RBE values, and equal effect per fraction for neutron irradiation of jejunal crypt cells. Radiat Res 134:295-300
Taylor, J M; Mendenhall, W M; Parsons, J T et al. (1992) The influence of dose and time on wound complications following post-radiation neck dissection. Int J Radiat Oncol Biol Phys 23:41-6
Taylor, J M; Mendenhall, W M; Lavey, R S (1992) Dose, time, and fraction size issues for late effects in head and neck cancers. Int J Radiat Oncol Biol Phys 22:3-11
Taylor, J M; Mendenhall, W M; Lavey, R S (1991) Time-dose factors in positive neck nodes treated with irradiation only. Radiother Oncol 22:167-73
Taylor, J M; Withers, H R; Mason, K A et al. (1991) Repopulation of mouse jejunal crypt cells. Radiother Oncol 20:181-90
Tucker, S L; Thames, H D; Taylor, J M (1990) How well is the probability of tumor cure after fractionated irradiation described by Poisson statistics? Radiat Res 124:273-82

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