Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
7R29CA047142-03
Application #
3458831
Study Section
Pathology B Study Section (PTHB)
Project Start
1988-05-01
Project End
1993-04-30
Budget Start
1990-01-01
Budget End
1990-05-31
Support Year
3
Fiscal Year
1989
Total Cost
Indirect Cost
Name
University of Southern California
Department
Type
Schools of Medicine
DUNS #
041544081
City
Los Angeles
State
CA
Country
United States
Zip Code
90033
Gopalakrishna, R; Chen, Z H; Gundimeda, U (1993) Nitric oxide and nitric oxide-generating agents induce a reversible inactivation of protein kinase C activity and phorbol ester binding. J Biol Chem 268:27180-5
Gundimeda, U; Hara, S K; Anderson, W B et al. (1993) Retinoids inhibit the oxidative modification of protein kinase C induced by oxidant tumor promoters. Arch Biochem Biophys 300:526-30
Gopalakrishna, R; Gundimeda, U; Wilson, J C et al. (1993) Multiwell filtration assay for rapid determination of protein phosphatase activity. Anal Biochem 212:296-9
Gopalakrishna, R; Chen, Z H; Gundimeda, U (1992) Irreversible oxidative inactivation of protein kinase C by photosensitive inhibitor calphostin C. FEBS Lett 314:149-54
Gopalakrishna, R; Chen, Z H; Gundimeda, U (1992) Nonphorbol tumor promoters okadaic acid and calyculin-A induce membrane translocation of protein kinase C. Biochem Biophys Res Commun 189:950-7
Gopalakrishna, R; Chen, Z H; Gundimeda, U et al. (1992) Rapid filtration assays for protein kinase C activity and phorbol ester binding using multiwell plates with fitted filtration discs. Anal Biochem 206:24-35
Gopalakrishna, R; Anderson, W B (1991) Reversible oxidative activation and inactivation of protein kinase C by the mitogen/tumor promoter periodate. Arch Biochem Biophys 285:382-7
Gopalakrishna, R; Anderson, W B (1989) Ca2+- and phospholipid-independent activation of protein kinase C by selective oxidative modification of the regulatory domain. Proc Natl Acad Sci U S A 86:6758-62