Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA059009-04
Application #
2099647
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1993-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Stegman, L D; Rehemtulla, A; Hamstra, D A et al. (2000) Diffusion MRI detects early events in the response of a glioma model to the yeast cytosine deaminase gene therapy strategy. Gene Ther 7:1005-10
Stegman, L D; Rehemtulla, A; Beattie, B et al. (1999) Noninvasive quantitation of cytosine deaminase transgene expression in human tumor xenografts with in vivo magnetic resonance spectroscopy. Proc Natl Acad Sci U S A 96:9821-6
Ross, B D; Zhao, Y J; Neal, E R et al. (1998) Contributions of cell kill and posttreatment tumor growth rates to the repopulation of intracerebral 9L tumors after chemotherapy: an MRI study. Proc Natl Acad Sci U S A 95:7012-7
Ben-Yoseph, O; Lyons, J C; Song, C W et al. (1998) Mechanism of action of lonidamine in the 9L brain tumor model involves inhibition of lactate efflux and intracellular acidification. J Neurooncol 36:149-57
Chenevert, T L; McKeever, P E; Ross, B D (1997) Monitoring early response of experimental brain tumors to therapy using diffusion magnetic resonance imaging. Clin Cancer Res 3:1457-66
Ross, B D; Bland, P; Garwood, M et al. (1997) Retrospective correction of surface coil MR images using an automatic segmentation and modeling approach. NMR Biomed 10:125-8
Stegman, L D; Ben-Yoseph, O; Freyer, J P et al. (1996) In vivo 31P MRS evaluation of ganciclovir toxicity in C6 gliomas stably expressing the herpes simplex thymidine kinase gene. NMR Biomed 9:364-8
Ben-Yoseph, O; Boxer, P A; Ross, B D (1996) Assessment of the role of the glutathione and pentose phosphate pathways in the protection of primary cerebrocortical cultures from oxidative stress. J Neurochem 66:2329-37
Ben-Yoseph, O; Camp, D M; Robinson, T E et al. (1995) Dynamic measurements of cerebral pentose phosphate pathway activity in vivo using [1,6-13C2,6,6-2H2]glucose and microdialysis. J Neurochem 64:1336-42
Ross, B D; Kim, B; Davidson, B L (1995) Assessment of ganciclovir toxicity to experimental intracranial gliomas following recombinant adenoviral-mediated transfer of the herpes simplex virus thymidine kinase gene by magnetic resonance imaging and proton magnetic resonance spectroscopy. Clin Cancer Res 1:651-7

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