Positron emission tomography (PET) has been utilized to image several types of tumors in vivo. PET has the advantage of providing functional information not obtainable with anatomic imaging modalities, such as mammography, ultrasound and magnetic resonance imaging. When used in conjunction with the glucose analog [fluorine-18] 2-deoxy-2-fluoro-D-glucose (FDG), PET has shown a high correlation with histological grade in tumors of the brain and musculoskeletal system. FDG uptake by astrocytomas correlates inversely with patient survival. Recently, PET-FDG has successfully imaged both primary breast carcinomas and axillary node metastases. Preliminary data demonstrate a significant difference in FDG uptake between benign and malignant breast lesions. There is a moderate correlation between FDG uptake in the primary malignancies and the presence of lymph nodes as detected by axillary node dissection. As treatment for breast cancer is determined by individual relapse risk, there is a need for more accurate stratification of patients into risk categories. Currently, the presence or absence of axillary nodal disease is the single most important prognostic factor. To make this determination from axillary node dissection has attendant costs and morbidity. This proposal seeks funding to study 100 women who have solid breast masses with PET-FDG prior to surgery. This study will assess the ability of PET-FDG to discriminate between benign and malignant breast lesions. The accuracy of PET-FDG at predicting the presence or absence of axillary node metastases as determined by axillary node dissection will be assessed. Finally, the uptake of FDG will be compared with patient survival statistics to determine if FDG uptake may be a strong prognostic factor for patient survival. If PET-FDG demonstrates new prognostic information for breast cancer, it will have profound implications on patient management.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29CA059854-01
Application #
3460753
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1993-05-14
Project End
1998-04-30
Budget Start
1993-05-14
Budget End
1994-04-30
Support Year
1
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Adler, Lee P; Weinberg, Irving N; Bradbury, Michelle S et al. (2003) Method for combined FDG-PET and radiographic imaging of primary breast cancers. Breast J 9:163-6
Chen, C H; Muzic Jr, R F; Nelson, A D et al. (1999) Simultaneous recovery of size and radioactivity concentration of small spheroids with PET data. J Nucl Med 40:118-30
Muzic Jr, R F; Chen, C H; Nelson, A D (1998) A method to correct for scatter, spillover, and partial volume effects in region of interest analysis in PET. IEEE Trans Med Imaging 17:202-13
Chen, C H; Muzic Jr, R F; Nelson, A D et al. (1998) A nonlinear spatially variant object-dependent system model for prediction of partial volume effects and scatter in PET. IEEE Trans Med Imaging 17:214-27
Adler, L P; Akhrass, R; Ma, D et al. (1997) False-positive parathyroid scan leading to sternotomy: incidental detection of a thymoma by C-11 methionine positron emission tomography. Surgery 122:116-9