Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA063931-03
Application #
2106108
Study Section
AIDS and Related Research Study Section 1 (ARRA)
Project Start
1994-05-01
Project End
1999-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Arkansas for Medical Sciences
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
City
Little Rock
State
AR
Country
United States
Zip Code
72205
Khanolkar, Aaruni; Fu, Zheng; Underwood, L Joey et al. (2003) CD4+ T cell-induced differentiation of EBV-transformed lymphoblastoid cells is associated with diminished recognition by EBV-specific CD8+ cytotoxic T cells. J Immunol 170:3187-94
Santin, A D; Bellone, S; Ravaggi, A et al. (2002) Induction of tumour-specific CD8(+) cytotoxic T lymphocytes by tumour lysate-pulsed autologous dendritic cells in patients with uterine serous papillary cancer. Br J Cancer 86:151-7
Clemons-Miller, A R; Chatta, G S; Hutchins, L et al. (2001) Intrathecal cytotoxic T-cell immunotherapy for metastatic leptomeningeal melanoma. Clin Cancer Res 7:917s-924s
Santin, A D; Hermonat, P L; Ravaggi, A et al. (2001) Expression of CD56 by human papillomavirus E7-specific CD8+ cytotoxic T lymphocytes correlates with increased intracellular perforin expression and enhanced cytotoxicity against HLA-A2-matched cervical tumor cells. Clin Cancer Res 7:804s-810s
Khanolkar, A; Yagita, H; Cannon, M J (2001) Preferential utilization of the perforin/granzyme pathway for lysis of Epstein-Barr virus-transformed lymphoblastoid cells by virus-specific CD4+ T cells. Virology 287:79-88
Santin, A D; Hermonat, P L; Ravaggi, A et al. (2000) Development, characterization and distribution of adoptively transferred peripheral blood lymphocytes primed by human papillomavirus 18 E7--pulsed autologous dendritic cells in a patient with metastatic adenocarcinoma of the uterine cervix. Eur J Gynaecol Oncol 21:17-23
Santin, A D; Bellone, S; Ravaggi, A et al. (2000) Induction of ovarian tumor-specific CD8+ cytotoxic T lymphocytes by acid-eluted peptide-pulsed autologous dendritic cells. Obstet Gynecol 96:422-30
Fu, Z; Cannon, M J (2000) Functional analysis of the CD4(+) T-cell response to Epstein-Barr virus: T-cell-mediated activation of resting B cells and induction of viral BZLF1 expression. J Virol 74:6675-9
Santin, A D; Hermonat, P L; Ravaggi, A et al. (2000) Development and therapeutic effect of adoptively transferred T cells primed by tumor lysate-pulsed autologous dendritic cells in a patient with metastatic endometrial cancer. Gynecol Obstet Invest 49:194-203
Santin, A D; Hermonat, P L; Ravaggi, A et al. (2000) Interleukin-10 increases Th1 cytokine production and cytotoxic potential in human papillomavirus-specific CD8(+) cytotoxic T lymphocytes. J Virol 74:4729-37

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