Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA064178-02
Application #
2106487
Study Section
Pathology A Study Section (PTHA)
Project Start
1995-01-01
Project End
1999-12-31
Budget Start
1996-01-01
Budget End
1996-12-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas MD Anderson Cancer Center
Department
Biology
Type
Other Domestic Higher Education
DUNS #
001910777
City
Houston
State
TX
Country
United States
Zip Code
77030
Marchetti, D; Li, J; Shen, R (2000) Astrocytes contribute to the brain-metastatic specificity of melanoma cells by producing heparanase. Cancer Res 60:4767-70
Walch, E T; Albino, A P; Marchetti, D (1999) Correlation of overexpression of the low-affinity p75 neurotrophin receptor with augmented invasion and heparanase production in human malignant melanoma cells. Int J Cancer 82:112-20
Walch, E T; Marchetti, D (1999) Role of neurotrophins and neurotrophins receptors in the in vitro invasion and heparanase production of human prostate cancer cells. Clin Exp Metastasis 17:307-14
Marchetti, D; Parikh, N; Sudol, M et al. (1998) Stimulation of the protein tyrosine kinase c-Yes but not c-Src by neurotrophins in human brain-metastatic melanoma cells. Oncogene 16:3253-60
Marchetti, D; Nicolson, G L (1997) Human melanoma cell invasion: selected neurotrophin enhancement of invasion and heparanase activity. J Investig Dermatol Symp Proc 2:99-105
Marchetti, D; Nicolson, G L (1997) Neurotrophin stimulation of human melanoma cell invasion: selected enhancement of heparanase activity and heparanase degradation of specific heparan sulfate subpopulations. Adv Enzyme Regul 37:111-34
Marchetti, D; Liu, S; Spohn, W C et al. (1997) Heparanase and a synthetic peptide of heparan sulfate-interacting protein recognize common sites on cell surface and extracellular matrix heparan sulfate. J Biol Chem 272:15891-7
Marchetti, D (1997) Specific degradation of subendothelial matrix proteoglycans by brain-metastatic melanoma and brain endothelial cell heparanases. J Cell Physiol 172:334-42
Marchetti, D; McQuillan, D J; Spohn, W C et al. (1996) Neurotrophin stimulation of human melanoma cell invasion: selected enhancement of heparanase activity and heparanase degradation of specific heparan sulfate subpopulations. Cancer Res 56:2856-63