Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA064230-03
Application #
2106575
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1994-07-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215
O'Donnell, Michael A; Luo, Yi; Hunter, Sharon E et al. (2004) Interleukin-12 immunotherapy of murine transitional cell carcinoma of the bladder: dose dependent tumor eradication and generation of protective immunity. J Urol 171:1330-5
O'Donnell, Michael A; Luo, Yi; Hunter, Sharon E et al. (2004) The essential role of interferon-gamma during interleukin-12 therapy for murine transitional cell carcinoma of the bladder. J Urol 171:1336-42
Nadler, R; Luo, Y; Zhao, W et al. (2003) Interleukin 10 induced augmentation of delayed-type hypersensitivity (DTH) enhances Mycobacterium bovis bacillus Calmette-Guerin (BCG) mediated antitumour activity. Clin Exp Immunol 131:206-16
Luo, Yi; Chen, Xiaohong; O'Donnell, Michael A (2003) Role of Th1 and Th2 cytokines in BCG-induced IFN-gamma production: cytokine promotion and simulation of BCG effect. Cytokine 21:17-26
Luo, Y; Chen, X; Han, R et al. (2001) Recombinant bacille Calmette-Guerin (BCG) expressing human interferon-alpha 2B demonstrates enhanced immunogenicity. Clin Exp Immunol 123:264-70
Pavlovich, C P; Kraling, B M; Stewart, R J et al. (2000) BCG-induced urinary cytokines inhibit microvascular endothelial cell proliferation. J Urol 163:2014-21
Luo, Y; Chen, X; Szilvasi, A et al. (2000) Co-expression of interleukin-2 and green fluorescent protein reporter in mycobacteria: in vivo application for monitoring antimycobacterial immunity. Mol Immunol 37:527-36
O'Donnell, M A; Luo, Y; Chen, X et al. (1999) Role of IL-12 in the induction and potentiation of IFN-gamma in response to bacillus Calmette-Guerin. J Immunol 163:4246-52
Luo, Y; Chen, X; Downs, T M et al. (1999) IFN-alpha 2B enhances Th1 cytokine responses in bladder cancer patients receiving Mycobacterium bovis bacillus Calmette-Guerin immunotherapy. J Immunol 162:2399-405
Alexandroff, A B; Jackson, A M; O'Donnell, M A et al. (1999) BCG immunotherapy of bladder cancer: 20 years on. Lancet 353:1689-94

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