Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA064374-02
Application #
2106798
Study Section
Experimental Therapeutics Subcommittee 1 (ET)
Project Start
1995-07-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Wright State University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
City
Dayton
State
OH
Country
United States
Zip Code
45435
Hermanson-Miller, Ingrid L; Turchi, John J (2002) Strand-specific binding of RPA and XPA to damaged duplex DNA. Biochemistry 41:2402-8
Smucker, E J; Turchi, J J (2001) TRF1 inhibits telomere C-strand DNA synthesis in vitro. Biochemistry 40:2426-32
Patrick, S M; Turchi, J J (2001) Stopped-flow kinetic analysis of replication protein A-binding DNA: damage recognition and affinity for single-stranded DNA reveal differential contributions of k(on) and k(off) rate constants. J Biol Chem 276:22630-7
Turchi, J J; Henkels, K M; Zhou, Y (2000) Cisplatin-DNA adducts inhibit translocation of the Ku subunits of DNA-PK. Nucleic Acids Res 28:4634-41
Hermanson, I L; Turchi, J J (2000) Overexpression and purification of human XPA using a baculovirus expression system. Protein Expr Purif 19:11-Jan
Patrick, S M; Turchi, J J (1999) Replication protein A (RPA) binding to duplex cisplatin-damaged DNA is mediated through the generation of single-stranded DNA. J Biol Chem 274:14972-8
Henkels, K M; Turchi, J J (1999) Cisplatin-induced apoptosis proceeds by caspase-3-dependent and -independent pathways in cisplatin-resistant and -sensitive human ovarian cancer cell lines. Cancer Res 59:3077-83
Turchi, J J; Henkels, K M; Hermanson, I L et al. (1999) Interactions of mammalian proteins with cisplatin-damaged DNA. J Inorg Biochem 77:83-7
Vaisman, A; Lim, S E; Patrick, S M et al. (1999) Effect of DNA polymerases and high mobility group protein 1 on the carrier ligand specificity for translesion synthesis past platinum-DNA adducts. Biochemistry 38:11026-39
Patrick, S M; Turchi, J J (1998) Human replication protein A preferentially binds cisplatin-damaged duplex DNA in vitro. Biochemistry 37:8808-15

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