Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA064466-02
Application #
2106959
Study Section
Pathology B Study Section (PTHB)
Project Start
1995-04-01
Project End
2000-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Pathology
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Wu, R; Connolly, D C; Dunn, R L et al. (2000) Restored expression of fragile histidine triad protein and tumorigenicity of cervical carcinoma cells. J Natl Cancer Inst 92:338-44
Wu, R; Connolly, D; Ngelangel, C et al. (2000) Somatic mutations of fibroblast growth factor receptor 3 (FGFR3) are uncommon in carcinomas of the uterine cervix. Oncogene 19:5543-6
Connolly, D C; Greenspan, D L; Wu, R et al. (2000) Loss of fhit expression in invasive cervical carcinomas and intraepithelial lesions associated with invasive disease. Clin Cancer Res 6:3505-10
Tashiro, H; Blazes, M S; Wu, R et al. (1997) Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies. Cancer Res 57:3935-40
Greenspan, D L; Connolly, D C; Wu, R et al. (1997) Loss of FHIT expression in cervical carcinoma cell lines and primary tumors. Cancer Res 57:4692-8
Kim, Y T; Thomas, N F; Kessis, T D et al. (1996) p53 mutations and clonality in vulvar carcinomas and squamous hyperplasias: evidence suggesting that squamous hyperplasias do not serve as direct precursors of human papillomavirus-negative vulvar carcinomas. Hum Pathol 27:389-95
Kessis, T D; Silberman, M A; Sherman, M et al. (1996) Rapid identification of patient specimens with microsatellite DNA markers. Mod Pathol 9:183-8
Kessis, T D; Connolly, D C; Hedrick, L et al. (1996) Expression of HPV16 E6 or E7 increases integration of foreign DNA. Oncogene 13:427-31
Isacson, C; Kessis, T D; Hedrick, L et al. (1996) Both cell proliferation and apoptosis increase with lesion grade in cervical neoplasia but do not correlate with human papillomavirus type. Cancer Res 56:669-74