Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29CA065525-01A1
Application #
2108538
Study Section
Metabolic Pathology Study Section (MEP)
Project Start
1996-03-15
Project End
2001-02-28
Budget Start
1996-03-15
Budget End
1997-02-28
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Hawaii
Department
Biochemistry
Type
Schools of Medicine
DUNS #
121911077
City
Honolulu
State
HI
Country
United States
Zip Code
96822
Beaver, Laura M; Kuintzle, Rachael; Buchanan, Alex et al. (2017) Long noncoding RNAs and sulforaphane: a target for chemoprevention and suppression of prostate cancer. J Nutr Biochem 42:72-83
Wong, Carmen P; Hsu, Anna; Buchanan, Alex et al. (2014) Effects of sulforaphane and 3,3'-diindolylmethane on genome-wide promoter methylation in normal prostate epithelial cells and prostate cancer cells. PLoS One 9:e86787
Beaver, Laura M; Buchanan, Alex; Sokolowski, Elizabeth I et al. (2014) Transcriptome analysis reveals a dynamic and differential transcriptional response to sulforaphane in normal and prostate cancer cells and suggests a role for Sp1 in chemoprevention. Mol Nutr Food Res 58:2001-13
Rajendran, Praveen; Kidane, Ariam I; Yu, Tian-Wei et al. (2013) HDAC turnover, CtIP acetylation and dysregulated DNA damage signaling in colon cancer cells treated with sulforaphane and related dietary isothiocyanates. Epigenetics 8:612-23
Wang, Rong; Löhr, Christiane V; Fischer, Kay et al. (2013) Epigenetic inactivation of endothelin-2 and endothelin-3 in colon cancer. Int J Cancer 132:1004-12
W Watson, Gregory; M Beaver, Laura; E Williams, David et al. (2013) Phytochemicals from cruciferous vegetables, epigenetics, and prostate cancer prevention. AAPS J 15:951-61
Parasramka, Mansi A; Dashwood, W Mohaiza; Wang, Rong et al. (2012) MicroRNA profiling of carcinogen-induced rat colon tumors and the influence of dietary spinach. Mol Nutr Food Res 56:1259-69
Beaver, Laura M; Yu, Tian-Wei; Sokolowski, Elizabeth I et al. (2012) 3,3'-Diindolylmethane, but not indole-3-carbinol, inhibits histone deacetylase activity in prostate cancer cells. Toxicol Appl Pharmacol 263:345-51
Parasramka, Mansi A; Ho, Emily; Williams, David E et al. (2012) MicroRNAs, diet, and cancer: new mechanistic insights on the epigenetic actions of phytochemicals. Mol Carcinog 51:213-30
Wang, Rong; Dashwood, Wan-Mohaiza; Nian, Hui et al. (2011) NADPH oxidase overexpression in human colon cancers and rat colon tumors induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP). Int J Cancer 128:2581-90

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