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Wierdl, Monika; Wall, Amelia; Morton, Christopher L et al. (2003) Carboxylesterase-mediated sensitization of human tumor cells to CPT-11 cannot override ABCG2-mediated drug resistance. Mol Pharmacol 64:279-88
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Wierdl, Monika; Morton, Christopher L; Harris, Linda C et al. (2003) p53-mediated regulation of expression of a rabbit liver carboxylesterase confers sensitivity to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11). J Pharmacol Exp Ther 304:699-705
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Morton, C L; Potter, P M (2000) Comparison of Escherichia coli, Saccharomyces cerevisiae, Pichia pastoris, Spodoptera frugiperda, and COS7 cells for recombinant gene expression. Application to a rabbit liver carboxylesterase. Mol Biotechnol 16:193-202
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Morton, C L; Wierdl, M; Oliver, L et al. (2000) Activation of CPT-11 in mice: identification and analysis of a highly effective plasma esterase. Cancer Res 60:4206-10
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Pawlik, C A; Iyengar, R V; Krull, E J et al. (2000) Use of the ornithine decarboxylase promoter to achieve N-MYC-mediated overexpression of a rabbit carboxylesterase to sensitize neuroblastoma cells to CPT-11. Mol Ther 1:457-63
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Potter, P M; McKenzie, P P; Hussain, N et al. (2000) Construction of adenovirus for high level expression of small RNAs in mammalian cells. Application to a Bcl-2 ribozyme. Mol Biotechnol 15:105-14
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Wierdl, M; Morton, C L; Danks, M K et al. (2000) Isolation and characterization of a cDNA encoding a horse liver butyrylcholinesterase: evidence for CPT-11 drug activation. Biochem Pharmacol 59:773-81
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Morton, C L; Wadkins, R M; Danks, M K et al. (1999) The anticancer prodrug CPT-11 is a potent inhibitor of acetylcholinesterase but is rapidly catalyzed to SN-38 by butyrylcholinesterase. Cancer Res 59:1458-63
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Potter, P M; Wolverton, J S; Morton, C L et al. (1998) Cellular localization domains of a rabbit and a human carboxylesterase: influence on irinotecan (CPT-11) metabolism by the rabbit enzyme. Cancer Res 58:3627-32
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Danks, M K; Morton, C L; Pawlik, C A et al. (1998) Overexpression of a rabbit liver carboxylesterase sensitizes human tumor cells to CPT-11. Cancer Res 58:20-2
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