Abstract

The foundation for the proposed hypothesis of this application assumes three critical steps to carcinogenesis as studied in the Syrian hamster kidney tumor model: 1) hormonal stimulation, 2) metabolic activation, 3) free radical generation.
The specific aims are to: 1) clone and characterize Syrian hamster ER cDNA; 2) study the effect of metabolic activation/free radical generation of ER gene expression; 3) characterize the role of metabolic/estrogenic potential on cell specific expression of ER proteins on tumorigenesis in hamster kidneys; and 4) investigate the role of metabolic activation of estrogens and the interdependency of, if any, between overexpression and neu suppression.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA066724-04
Application #
6137546
Study Section
Biochemical Endocrinology Study Section (BCE)
Program Officer
Yang, Shen K
Project Start
1997-01-01
Project End
2001-12-31
Budget Start
2000-01-01
Budget End
2000-12-31
Support Year
4
Fiscal Year
2000
Total Cost
$110,718
Indirect Cost

  Institution

Name
Charles R. Drew University of Medicine & Science
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
785877408
City
Los Angeles
State
CA
Country
United States
Zip Code
90059

  Publications

Chen, Tzu-An; O'Connor, Teresia M; Hughes, Sheryl O et al. (2013) TV parenting practices: is the same scale appropriate for parents of children of different ages? Int J Behav Nutr Phys Act 10:41
O'Connor, Teresia M; Chen, Tzu-An; Baranowski, Janice et al. (2013) Physical activity and screen-media-related parenting practices have different associations with children's objectively measured physical activity. Child Obes 9:446-53
Baranowski, Tom; Abdelsamad, Dina; Baranowski, Janice et al. (2012) Impact of an active video game on healthy children's physical activity. Pediatrics 129:e636-42