Heat Shock Protein Function as A Therapeutic Target

Whitesell, Luke J.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: First Independent Research Support & Transition (FIRST) Awards (R29)
• Project #: 1R29CA069537-01
• Application #: 2113595
• Study Section: Experimental Therapeutics Subcommittee 1 (ET)
• Project Start: 1996-05-01
• Project End: 2001-04-30
• Budget Start: 1996-05-01
• Budget End: 1997-04-30
• Support Year: 1
• Fiscal Year: 1996

Institution

• Name: University of Arizona
• Department: Pediatrics
• Type: Schools of Medicine
• City: Tucson
• State: AZ
• Country: United States
• Zip Code: 85721

Publications

Whitesell, L; Sutphin, P; An, W G et al. (1997) Geldanamycin-stimulated destabilization of mutated p53 is mediated by the proteasome in vivo. Oncogene 14:2809-16

Whitesell, L; Cook, P (1996) Stable and specific binding of heat shock protein 90 by geldanamycin disrupts glucocorticoid receptor function in intact cells. Mol Endocrinol 10:705-12