Abstract

The work proposed focuses on a number of questions concerning the diagnosis, natural history, study design and role of markers in the prognosis and tracking of prostate cancer. Adaptation and development of statistical methodology is central, but useful results are targets, based on a number of data sets available to the investigator.
Aim (i) deals with the shift in biomarker growth rate with the advent of frank diagnosis and involves the study of cases and controls in longitudinal tracking, with special

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA070227-05
Application #
6173186
Study Section
Special Emphasis Panel (ZRG7-STA (01))
Program Officer
Erickson, Burdette (BUD) W
Project Start
1996-08-01
Project End
2002-07-31
Budget Start
2000-08-01
Budget End
2002-07-31
Support Year
5
Fiscal Year
2000
Total Cost
$126,297
Indirect Cost

  Institution

Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
078200995
City
Seattle
State
WA
Country
United States
Zip Code
98109

  Publications

Etzioni, Ruth; Kooperberg, Charles; Pepe, Margaret et al. (2003) Combining biomarkers to detect disease with application to prostate cancer. Biostatistics 4:523-38
Etzioni, Ruth; Berry, Kristin M; Legler, Julie M et al. (2002) Prostate-specific antigen testing in black and white men: an analysis of medicare claims from 1991-1998. Urology 59:251-5
Etzioni, Ruth; Penson, David F; Legler, Julie M et al. (2002) Overdiagnosis due to prostate-specific antigen screening: lessons from U.S. prostate cancer incidence trends. J Natl Cancer Inst 94:981-90
Baker, S G (2000) Identifying combinations of cancer markers for further study as triggers of early intervention. Biometrics 56:1082-7
Etzioni, R; Cha, R; Cowen, M E (1999) Serial prostate specific antigen screening for prostate cancer: a computer model evaluates competing strategies. J Urol 162:741-8
Etzioni, R; Pepe, M; Longton, G et al. (1999) Incorporating the time dimension in receiver operating characteristic curves: a case study of prostate cancer. Med Decis Making 19:242-51
Etzioni, R; Legler, J M; Feuer, E J et al. (1999) Cancer surveillance series: interpreting trends in prostate cancer--part III: Quantifying the link between population prostate-specific antigen testing and recent declines in prostate cancer mortality. J Natl Cancer Inst 91:1033-9
Etzioni, R; Cha, R; Feuer, E J et al. (1998) Asymptomatic incidence and duration of prostate cancer. Am J Epidemiol 148:775-85
Etzioni, R D; Weiss, N S (1998) Analysis of case-control studies of screening: impact of misspecifying the duration of detectable preclinical pathologic changes. Am J Epidemiol 148:292-7