The objectives of this proposal are to reveal the molecular mechanisms of NE cell differentiation in the prostate, characterize new markers for future clinical applications, and help clarify the biological significance of this phenomenon.
The aims are to 1) determine the changes in gene expression involved in the process of in vitro-induced NE differentiation of CaP cells; 2) molecularly and functionally characterize thyroid stimulating hormone (TSH)-like peptide, one of the most abundant peptides in NE differentiation of CaP cells; and 3) determine the proliferation status of the induced NE cells and their paracrine effects in co-culture on CaP cell lines in the absence and presence of androgens.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29CA072872-01
Application #
2010929
Study Section
Biochemical Endocrinology Study Section (BCE)
Project Start
1997-01-15
Project End
2001-11-30
Budget Start
1997-01-15
Budget End
1997-11-30
Support Year
1
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Rochester
Department
Urology
Type
Schools of Dentistry
DUNS #
208469486
City
Rochester
State
NY
Country
United States
Zip Code
14627