The goal is to develop a clinical prototype of the Laser Optoacoustic Imaging System (LOIS), a new concept in diagnostic imaging of breast cancer.
Specific aims focus on (1) tests of LOIS using phantoms resembling optical and mechanical properties of breast with tumors, (2) the system improvement on the basis of results of initial tests, (3) evaluation of the system using mastectomy specimens, (4) modification of the system in preparations for the in vivo clinical trials and finally, (5) clinical trials on 50-100 patients. In vivo optical tomography studies suggest that enhanced light absorption in breast cancer compared with normal breast tissues can help to reveal malignant tumors on the basis of optical contrast. The hypothesis is that LOIS utilizing sensitive detection of pressure waves preferentially induced by laser pulses in tumors will provide breast cancer images with greater contrast and sensitivity compared with x-ray mammography, ultrasonography or optical tomography. The major idea is that energy of short laser pulses absorbed primarily in tumors will create sources of pressure waves in ultrasonic frequency range. The ultrasonic waves will deliver diagnostic information to the breast surface, where signals can be detected by piezoelectric transducers. Reconstruction of a three-dimensional image of breast will be obtained on the basis of time-resolved detection and analysis of profiles of laser-induced pressure distribution recorded with a number of transducers located along the breast surface. Modalities presently applied for breast cancer detection are not free of serious limitations. The applicants propose to combine advantages of optical and ultrasonic imaging in one advanced tomography.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29CA080221-04
Application #
6377012
Study Section
Diagnostic Imaging Study Section (DMG)
Program Officer
Torres-Anjel, Manuel J
Project Start
1998-05-22
Project End
2003-04-30
Budget Start
2001-05-09
Budget End
2002-04-30
Support Year
4
Fiscal Year
2001
Total Cost
$104,060
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Ophthalmology
Type
Schools of Medicine
DUNS #
041367053
City
Galveston
State
TX
Country
United States
Zip Code
77555
Ermilov, Sergey A; Khamapirad, Tuenchit; Conjusteau, Andre et al. (2009) Laser optoacoustic imaging system for detection of breast cancer. J Biomed Opt 14:024007
Andreev, Valeriy G; Karabutov, Alexander A; Oraevsky, Alexander A (2003) Detection of ultrawide-band ultrasound pulses in optoacoustic tomography. IEEE Trans Ultrason Ferroelectr Freq Control 50:1383-90