The overall goal of this application is to understand the basic biochemical events at the taste receptor cell level by studying generation of second messengers in mammalian bitter taste. The animal model chosen is the SWR/J strain of mice, sensitive to a number of bitter compounds. The mechanism of bitter taste transduction will be studied using rapid kinetic methodology, and the second messengers IP3, DAG, cAMP and cGMP will be measured in response to a variety of bitter stimuli. Results obtained from these studies may lead to the development of molecules that enhance or suppress bitter taste.

Agency
National Institute of Health (NIH)
Institute
National Institute of Dental & Craniofacial Research (NIDCR)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
1R29DE010754-01A1
Application #
2131661
Study Section
Oral Biology and Medicine Subcommittee 1 (OBM)
Project Start
1994-08-01
Project End
1999-07-31
Budget Start
1994-08-01
Budget End
1995-07-31
Support Year
1
Fiscal Year
1994
Total Cost
Indirect Cost
Name
New York University
Department
Dentistry
Type
Schools of Dentistry
DUNS #
004514360
City
New York
State
NY
Country
United States
Zip Code
10012
Zaidi, M; Shankar, V S; Adebanjo, O A et al. (1996) Regulation of extracellular calcium sensing in rat osteoclasts by femtomolar calcitonin concentrations. Am J Physiol 271:F637-44