Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
3R29DK042807-05S1
Application #
2142560
Study Section
Endocrinology Study Section (END)
Project Start
1990-08-01
Project End
1996-01-01
Budget Start
1994-08-01
Budget End
1996-01-01
Support Year
5
Fiscal Year
1994
Total Cost
Indirect Cost
Name
East Carolina University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Greenville
State
NC
Country
United States
Zip Code
27858
Flynn, T R; Hollenberg, A N; Cohen, O et al. (1994) A novel C-terminal domain in the thyroid hormone receptor selectively mediates thyroid hormone inhibition. J Biol Chem 269:32713-6
Usala, S J (1994) Resistance to thyroid hormone in children. Curr Opin Pediatr 6:468-75
Hao, E; Menke, J B; Smith, A M et al. (1994) Divergent dimerization properties of mutant beta 1 thyroid hormone receptors are associated with different dominant negative activities. Mol Endocrinol 8:841-51
Geffner, M E; Su, F; Ross, N S et al. (1993) An arginine to histidine mutation in codon 311 of the C-erbA beta gene results in a mutant thyroid hormone receptor that does not mediate a dominant negative phenotype. J Clin Invest 91:538-46
Klann, R C; Torres, B; Menke, J B et al. (1993) Competitive polymerase chain reaction quantitation of c-erbA beta 1, c-erbA alpha 1, and c-erbA alpha 2 messenger ribonucleic acid levels in normal, heterozygous, and homozygous fibroblasts of kindred S with thyroid hormone resistance. J Clin Endocrinol Metab 77:969-75
Ways, D K; Qin, W; Cook, P et al. (1993) Dominant and nondominant negative C-erbA beta 1 receptors associated with thyroid hormone resistance syndromes augment 12-O-tetradecanoyl-phorbol-13-acetate induction of the collagenase promoter and exhibit defective 3,5,3'-triiodothyronine-mediated repre Mol Endocrinol 7:1112-20
Refetoff, S; Weiss, R E; Usala, S J (1993) The syndromes of resistance to thyroid hormone. Endocr Rev 14:348-99
Meier, C A; Dickstein, B M; Ashizawa, K et al. (1992) Variable transcriptional activity and ligand binding of mutant beta 1 3,5,3'-triiodothyronine receptors from four families with generalized resistance to thyroid hormone. Mol Endocrinol 6:248-58
Cugini Jr, C D; Leidy Jr, J W; Chertow, B S et al. (1992) An arginine to histidine mutation in codon 315 of the c-erbA beta thyroid hormone receptor in a kindred with generalized resistance to thyroid hormones results in a receptor with significant 3,5,3'-triiodothyronine binding activity. J Clin Endocrinol Metab 74:1164-70
Burman, K D; Djuh, Y Y; Nicholson, D et al. (1992) Generalized thyroid hormone resistance: identification of an arginine to cystine mutation in codon 315 of the c-erb A beta thyroid hormone receptor. J Endocrinol Invest 15:573-9

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