The goal of this project is to determine the sensory and effector mechanisms mediating enterogastric reflex inhibition of gastric acid secretion by intestinal fat. Because cholecystokinin is emerging as a physiological regulator of acid secretion, its role in enterogastric acid inhibition specifically will be investigated. Indeed, this study is based on recent evidence indicating that CCK may stimulate a vago-vagal reflex inhibitory pathway from the intestine to the stomach. It is well known that the presence of nutrients in the intestine after a meal stimulates pancreatic protein and biliary secretion during the post- prandial period. In addition, dietary fats are an especially potent inhibitor of gastric emptying and acid secretion. There is good evidence that CCK is mediating at least the acid inhibitory response, but the transmission process and effector mechanism for the alteration of gastric acid secretion are not yet known. It is still not clear if CCK is acting principally as a hormonal inhibitor of acid secretion, or whether it can exert its effect on the stomach by neurally-mediated, paracrine release of gastric somatostatin. Therefore, this project will use in vivo regulatory physiology, electrophysiology, and immunohistochemistry to thoroughly investigate the enterogastric inhibitory pathways. Because CCK is a prime candidate to initiate this effect, these studies also will address the mechanisms of action of CCK as an enterogastrone.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
First Independent Research Support & Transition (FIRST) Awards (R29)
Project #
5R29DK045752-03
Application #
2144989
Study Section
General Medicine A Subcommittee 2 (GMA)
Project Start
1993-09-25
Project End
1998-08-31
Budget Start
1995-09-01
Budget End
1996-08-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095